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黔东南州8月龄~6岁儿童乙脑疫苗强化免疫前后抗体水平监测 预览

SURVEILLANCE OF JAPANESE B ENCEPHALITIS VACCINE ANTIBODY LEVEL BEFORE AND AFTER STRENGTHENING IMMUNIZATION FOR CHILDREN OF 8 MONTHS-6 YEARS OLD IN QIANDONGNAN PREFECTURE
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摘要 [目的]了解乙脑疫苗强化免疫前后目标儿童抗体水平,为预防和控制乙脑提供科学依据。[方法]采用分层随机抽样方法,在免疫前和免疫后1个月采血,用反向被动凝集抑制试验检测血清抗体。[结果]免疫后目标儿童血清抗体阳性率由免疫前的34.71%上升至免疫后的99.16%,抗体几何平均滴度(GMT)由1:3.40上升为1:138.69;免疫前血清抗体阴性的儿童、免疫后抗体阳转率为98.78%。免疫后不同年龄、性别、民族、地区和免疫史的儿童血清抗体水平差异无统计学意义.免疫前抗体水平低者免疫后抗体阳转率高。[结论]强化免疫后目标儿童血清抗体水平明显升高,各年龄组均达到了96%以上的免疫成功率指标,具有较好的保护效果;免疫后血清抗体水平不受年龄、性别、民族、地区和免疫史等因素的影响。 [ Objective] To understand the Japanese B Encephalitis (JBE) vaccine antibody level before and after strengthening immunization and provide the scientific basis for controlling JBE in the future. [ Methods] Used stratified randomization sampling method, the sera samples one month prior and post vaccination were collected and tested by RPHI assay for antibody response. [Results] The antibody positive rate of children raised from 34.71% to 99.16%, the GMT from 1 : 3.4 to 1 : 138.69; the antibody positive rates of the children whose JBE antibody were negative before immunization was 98.78% after inactivated JBE vaccination. The serum antibody level had no difference in the children's age, sex, race, region and immunity history. The lower the Children antibody' s level was before the immunity, the higher the children's antibody positive rate was after the immunity. [ Conclusion ] The children serum antibody level obviously goes up after strengthening immunization, the immunity success rate which all come to above 96% in each age group. The protection effect is better; the children antibody level is uninfluenced by age, sex, race, region and immunity history, etc. after the immunity.
作者 罗涛 唐德亮 王芳 邓茂铭 潘宏 刘静 LUO Tao, TANG De-liang, WANG fang, et al ( Qiandongnan Prefecture Centre for Disease Control and Prevention in Guizhou, Kaili 556000, China)
出处 《现代预防医学》 CAS 北大核心 2008年第21期 4156-4158,共3页 Modern Preventive Medicine
关键词 乙脑疫苗 强化免疫 抗体 监测 Japanese B encephalitis (JBE) vaccines Strengthening immunization Antibody Surveillance
作者简介 罗涛(1964-)男,本科,副主任医师,研究方向:疾病预防控制.
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