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2006—2007年四川省流行性乙型脑炎临床病例血清学分析 预览 被引量:9

Serological Detection of Clinical Japanese Encephalitis Cases in Sichuan Province in 2006 and 2007
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摘要 目的通过对四川省流行性乙型脑炎临床病例血清学检测,核实乙脑病例诊断和了解病毒性脑炎(VE)发病情况。方法采用ELISA法对2006—2007年四川省内医院临床诊断为乙脑病例的血清和脑脊液标本进行乙脑和部分病毒性脑炎的血清抗体检测。结果2006~2007年分别收到各地送检病例880和334例血清和脑脊液标本,进行乙脑IgM和IgG抗体检测,乙脑抗体阳性分别为701例和221例,血清学确诊率分别为79.66%和66.17%。对乙脑抗体阴性病例116份(2006年)和102份(2007年)血清标本进行部分病毒性脑炎IgM抗体检测,2006年埃可病毒、柯萨奇病毒、单纯疱疹病毒I型和腮腺炎病毒阳性率分别为7.76%、21.55%、20.69%和2.59%;2007年埃可病毒、单纯疱疹病毒I型和腮腺炎病毒阳性率分别为4.90%、2.94%和14.71%,柯萨奇病毒IgM抗体未检出。结论四川省夏季病毒性脑炎的流行仍以乙脑为主,除乙脑外其他病毒引起的病毒性脑炎也应引起相应重视。 Objective To verify the diagnosis of Japanese encephalitis virus B type cases and to investigate the incidence of the disease in Sichuan Province. Methods The serum antibody of encephalitis virus B type and other encephalitis virus were detected from serum and/or CSF samples from clinically diagnosed cases during 2006 -2007 with ELISA. Results In 2006, 1 199 cases were clinical reported as encephalitis virus B type and 880 cases of serum and/or CSF samples were detected, and the incidence of serum diagnosis was 73.39%. In 2007, the incidence of serum diagnosis was 61.74%, which was from 580 Clinical reported cases and 334 cases of serum and/or CSF samples. In the antibody detection of JE IgM and IgG antibody test, 701 and 221 cases showed positive and the serum verification rate was 79.66% and 66. 17%, respectively, overall 116 serum samples( from 2006)and 102 serum samples (from 2007) which encephalitis virus antibody negative were carried out for detection virus encephalitis IgM, and the positive incidence of ECHO virus, Coxsackie viruses, herpes simplex virus and mumps virus were 7.76%, 21.55%, 20. 69% and 2. 59% in 2006 and 4. 90%, 0%, 2. 94% and 14. 71% in 2007 respectively. Conclusion The epidemic encephalitis virus is still predominant by encephalitis virus B type in summer in Sichuan Province. However, the virus encephalitis caused by other virus should also be paid much attention.
作者 张佳珂 林世华 陈丹林 周兴余 刘学成 ZHANG Jia-ke, LIN Shi-hua, CHEN Dan-lin, et al( Sichuan Center for Disease Control and Prevention. Chengdu 610041, Sichuan Province, China)
出处 《预防医学情报杂志》 CAS 2008年第12期 978-980,共3页 Journal of Preventive Medicine Information
关键词 流行性乙型脑炎 病毒性脑炎 血清学检测 Epidemical encephalitis virus B type Virus encephalitis Serum detection
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