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江苏省麻疹流行病学分析 预览 被引量:31

Analysis of epidemiological and elimination strategies on measles in Jiangsu province
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摘要 目的了解江苏省2005~2007年麻疹疫情特征及麻疹野毒株的基因特征,为进一步控制和消除麻疹提供依据。方法对麻疹发病情况进行描述流行病学分析;对本省分离的116株麻疹病毒进行分子流行病学研究。结果2005--2007年麻疹疫情明显上升,发病率分别达11.13/10万,6.10/10万和7.23/10万。各省辖市中苏州市发病率一直居于首位,其次是经济较发达地区,一些经济欠发达地区也存在数年一次的麻疹高发现象。2005~2007年〈8月龄儿童病例分别占总病例数的10.83%,12.88%,10.98%;≥15岁成人病例分别占总病例数的46.12%。43.19%,44.52%;〈8月龄儿童和≥15岁成人麻疹病例合计占总病例数的55%以上。流动人口麻疹病例主要集中在苏州、常州、无锡市等经济发达地区。2003年至今分离116株麻疹野毒株,均为H1基因型的H1a基因亚型。结论麻疹发病年龄分布已全面呈现“双向移位”现象;流动人口已成为经济发达地区麻疹发病的主要人群;H1a基因亚型为江苏省广泛流行优势基因亚型。 Objective To explore epidemiological characterization and genetic characterization of wild- type measles viruses in Jiangsu province between 2005 and 2007, and to provide evidence for strategies and measures of measles control and elimination. Methods Descriptive epidemiological analysis was conducted for measles epidemiology. Genetic characterization of 116 measles viruses isolated from throat swabs of measles patients in Jiangsu province was studied. Results The reported measles incidence rate of Jiangsu province in 2005,2006 and 2007 was 11.13, 6.10 and 7.23 per 100,000, respectively. The highest incidence rate of all the 13 cities was found in Suzhou and other developed cities. Measles incidence exhibited yearly circle in some developing cities. The proportion of measles cases aged less than 8 months in 2005, 2006 and 2007 was 10.83 %, 12.88 % and 10.98 %, respectively and that of more than 14 years old was 46.12 %, 43.19 %, and 44.52 %, respectively. Measles cases of migrant working population mustered in Suzhou, Changzhou and Wuxi. 116 measles viruses isolated during the years of 2003 -2007 were all identified as H1a sub - genotype of H1 genotype. Conclusion The epidemiological characterization of age distribution of measles in Jiangsu province has been changed in 2005 - 2007. Measles cases of less than 1 and more than 14 years old increased. In the developed cities, most of the measles cases are among migrant working population. H1a sub - genotype was the major genotype of wild type measles viruses found in Jiangsu province.
作者 陶红 许文波 陆培善 姬奕昕 还锡萍 许松涛 马福宝 TAO Hong, XU Wen-bo, LU Pei- shan , et al .( Section of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention ( Nanjing 210009, China ))
出处 《中国公共卫生》 CAS CSCD 北大核心 2008年第12期 1508-1510,共3页 Chinese Journal of Public Health
基金 江苏省“135”工程项目(RC2001066)
关键词 麻疹 疫情特征 基因型别 消除策略 measles epidemiology genotype elimination strategy
作者简介 陶红(1965-),女,江苏江阴人,副主任医师,学士,主要从事传染病的预防和控制工作。
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