[ Objective ] To explore the effects of cm＇cumin on invasion and metastasis of the human cervical cancer cells Caski and to investigate the possible mechanism. [Method] Caski cells were treated with 10, 25, and 50 μmol/L curcumin for 24, 48, and 72 h, respectively. Proliferation of Caski cells was measured with MTT assay. Invasion and metastasis of Caski cells were evaluated with Transwell chamber. The expression of MMP-2, MT1-MMP, and NF-κB were detected by Western blot. [Result] After being treated with curcumin, the proliferation of Caski cells was inhibited in a time and dose-depending manner. The invasion and metastasis of Caski cells were also inhibited. The expression level of MMP-2, MT1-MMP, and NF-κB were decreased. [Conclusion] Curcumin could affect the invasion and metastasis of the human cervical cancer cells Caski. It is probably one of its molecular mechanisms to inhibit the expression of MMP-2, MT1-MMP, and NF-κB.
Journal of Sun Yat-Sen University:Medical Sciences