Objective：One case of central nervous system myelomatosis （CNS MM） after autologous stem cell transplantation was reported. The correlative literatures were reviewed. Methods：One patient with IgA h type MM was treated by 3 courses of VAD chemotherapy, followed by auto - stem cell transplantation was adopted. Clinical manifestations and blood biochemical markers suggested relapse after 2 - 3 months. Progressing osteolytic lesions and relapsed multiple subcutaneous nodes of plasma cells spreaded all over. Various combination hemotherapies, bortezomib and irradiation therapy were applied. Combination chemotherapy consisted of VAD, MOP,TCD ,TDCEP schedules. The case was refractory for various treatments after relapsed. The time of CNS MM diagnosis was at systemic remission of MM. Tumor cells in CSF were disappear and biochemical changes of CSF became normal by intrathecal chemotherapies （IT）. Obstructed jaundice induced by plasma cell tumor in head of pancreas and relapsed CNS MM were died cause. Results：Interval time from MM to CNS MM was 26 months,from auto - SCT to CNS MM was 15 months. Overall survival time was 33.5 months,from auto- SCT to death 22.5 months,from CNS MM to death 7.5 months. Conclusion：Involvement of the CNS in MM is very uncommon. The prognosis of CNS MM is very poor, median overall survival of 1.5 - 2 months according to reported. CNS MM is treated with various combinations and treatment schedules of SC ,IT and CI. The treatment schedules used for CNS MM are heterogeneous and a superior treatment schedule is ruled out. IC should be included in any treatment modality.
autologous stem cell transplantation
central nervous system myelomatosis