The degradability of the α-CS and β-CS bioactive macroporous bioceramic in vitro and in vivo were comparatively studied, and the results were compared with β-tricalcium phosphate （ β-Ca3 （ PO4 ）2, β-TCP） macroporous bioceramics. The macroporous α-CS, β-CS and β-TCP bioceramics were obtained after sintering at high temperature . The degradability of macroporous bioceramics in vitro was determined by their weight loss percentage in Tris - HCl buffer solution after soaking for 1, 3 and 7 days. In the experiment in vivo, the ceramic samples were implanted in a rabbit condyles of femur defect model, and the specimens were harvested after 1,4 , 8 and 12 weeks, respectively. Degradation of the grafts were evaluated by the means of histological and histomor- phometry after 1, 4 , 8 and 12 weeks of implantation. The experiment in vitro result showed that the degradation rate was β-CS 〉 α-CS 〉 β-TCP. There is no obviously difference in statistics between β-CS and α-CS （ P 〉 0.05 ）. There is obviously difference in statistics between β-TCP and CS. In the experiment in vivo, the histological and histomorphometry results showed that the degradation rate was β-CS 〉 α-CS 〉 β-TCP, but there is no obviously difference in statistics. The present studies showed that the degradability of the porous β-CS and α-CS ceramics is much faster than that of β-TCP. Therefore, both of the β-CS and α-CS macroporous bioceramics could be used as bioactive and biodegradable materials for hard tissue repair and tissue engineering applications.
Science Technology and Engineering
bone defect bone transplantation bone regeneration calcium silicate tricalcium phosphate artificial bone degradiation