期刊文献+

细胞重编程的分子机制

Molecular mechanisms of cell reprogramming
分享 导出
摘要 细胞重编程,尤其是诱导多能性干细胞的出现,给再生医学带来极大的希望。近年来,这方面的研究吸引了众多科学家的参与,也取得了非常丰富的成果。本文主要从转录因子、表观遗传和信号转导等角度,介绍了细胞重编程分子机制研究方面的进展和未来的方向。 Cell reprogramming, especially the generation of induced pluripotent stem cells (iPSC) has opened a new horizon in the treatment of degenerative illnesses. Studies on the generation and mechanisms of iPSC have been the hot-spot and breathtaking progresses, which have been made since the first report on the iPSC generation. In the present paper we review the role and molecular mechanism of transcription factors, epigenetic regulation and cell signaling in cell reprogramming.
作者 陈涛涛 康九红 CHEN Tao-tao, KANG Jiu-hong (1 Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; 2School of Life Science and Technology, Tongji University, Shanghai 200092, China)
出处 《生命科学》 CSCD 北大核心 2009年第3期353-356,共4页 Chinese Bulletin of Life Sciences
基金 国家自然科学基金(30625014 90919028)
关键词 细胞重编程 诱导多能性干细胞 转录因子 表观遗传 信号转导 cell reprogramming induced pluripotent stem cell transcription factor epigenetics cell signaling
作者简介 通讯作者:E—mail:jhkang@tongji.edu.cn
  • 相关文献

参考文献32

  • 1Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell, 2007, 1(1): 39-49 被引量:1
  • 2Daley GQ, Lensch MW, Jaenisch R, et al. Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell, 2009, 4(3): 200-1 被引量:1
  • 3Yu J, Hu K, Smuga-Otto K, et al. Human induced pluripotent stem ceils free of vector and lransgene sequences, Science, 2009, [Epub ahead of print] 被引量:1
  • 4Kaji K, Norrby K, Paca A, et al. Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature, 2009, 458(7239): 771-5 被引量:1
  • 5Woltjen K, Michael IP, Mohseni P, et al. Piggybac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature, 2009, 458(7239): 766-70 被引量:1
  • 6Brambrink T, Foreman R, Welstead GG, et al. Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell, 2008, 2(2): 151-9 被引量:1
  • 7Maherali N, Sridharan R, Xie W, et al. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell, 2007, 1(1): 55-70 被引量:1
  • 8Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 2006, 126(4): 663-76 被引量:1
  • 9Okita K, Ichisaka T, Yamanaka S. Generation of germlinecompetent induced pluripotent stem cells. Nature, 2007, 448(7151): 313-7 被引量:1
  • 10Wemig M, Meissner A, Foreman R, et al. In vitro reprogramming of fibroblasts into a pluripotent ES-eell-like state. Nature, 2007, 448(7151): 318-24 被引量:1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈