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2007年中国CHINET葡萄球菌属耐药性监测 预览 被引量:45

CHINET 2007 surveillance of antibiotic resistance in Staphylococcus isolates in China
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摘要 目的了解国内不同地区临床分离葡萄球菌属对抗菌药物的耐药性。方法联合中国12所综合性医院,按统一方案、采用统一的材料、方法(Kirby-Bauer)和判断标准(CLSI2007年版)进行葡萄球菌属的耐药性监测。结果6048株葡萄球菌属临床分离株中金葡菌占56.0%,凝固酶阴性葡萄球菌占44.0%。凝固酶阴性葡萄球菌中主要有表皮葡萄球菌(26.7%)、溶血葡萄球菌(7.7%)和人型葡萄球菌(3.3%)等。金葡菌和凝固酶阴性葡萄球菌中耐甲氧西林株分别占58.3%(15.3%~80.4%)和75.0%(63.0%~100%)。未发现万古霉素中介和耐药株(VISA和VRSA)。约50%~70.8%的MRSA对利福平、磷霉素和复方磺胺甲口恶唑敏感。MRCNS中约60%和90%菌株分别对磷霉素和利福平敏感。不同地区、不同医院葡萄球菌属的耐药性各具特点。不同医院的分离菌对同一种药物的耐药率有很大差异。结论加强细菌耐药性监测,所得结果对于了解细菌耐药性变迁和指导临床用药有很大参考价值。 Objective To investigate the resistance of clinical strains of Staphylococcus isolated from hospitals in several regions of China during 2007. Methods Twelve representative general hospitals were involved in this program. Bacterial susceptibility testing was carried out by means of a unified protocol using Kirby-Bauer method. Results were analyzed according to CLSI 2007 standards. Results Of 6 048 clinical Staphylococcus isolates, S. aureus and coagulase negative Staphylococcus (CNS) accounted for 56. 0% and 44.0%, respectively. S. epidermidis (26. 7%), S. haemolyticus (7.70/00) and S. hominis (3.3%) were major species of coagulase-negative Staphylococcus. The prevalence of methieillin-resistant Staphylococcus was 58.30% (15, 3% to 80.4%) in S. aureus and 75.0% (63.0%-100%) in CNS. No vanco- mycin-resistant strain (VISA or VRSA) was found. About 50%-70.8% of MRSA strains were susceptible to rifampin, SMZ-TMP and fosfomycin. About 60% and 90% of MRCNS were susceptible to fosfomycin and refampin respective ly. The resistance of Staphylococcus varied widely with region or hospital. Conclusions The data from the ongoing nationwide bacterial resistance surveillance by means of a unified protocol are very important and valuable for rational antimicrobial therapy.
作者 朱德妹 胡付品 汪复 阮斐怡 倪语星 孙景勇 俞云松 杨青 王传清 薛建昌 徐英春 孙宏莉 张泓 李万华 孙自镛 简翠 胡云健 艾效曼 苏丹虹 卓超 魏莲花 吴玲 贾蓓 黄文祥 张朝霞 季萍 ZHU De-mei, HU Fu-pin, WANG Fu, RUAN Fei-yi, NI Yu-xing, SUN Jing-yong, YU Yun-song , YANG Qing , WANG Chuan-qing , XUE J ian-chang , XU Ying-chun , SUN Hong-Li , ZHANG Hong , LI Wan-hua , SUN Zi-yong , JIAN Cui , HU Yun-jian , AI Xiao-man , SU Dan-hong , ZHUO Chao , WEI Lian-hua , WU Ling, JIA Bei , HUANG Wen-xiang , ZHANG Zhao-xia, JI Ping. (Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China)
出处 《中国感染与化疗杂志》 CAS 2009年第3期 168-174,共7页 Chinese Journal of Infection and Chemotherapy
关键词 葡萄球菌 细菌耐药性监测 抗菌药 药敏试验 Staphylococcus surveillance of bacterial resistance antimicrobial agent bacterial susceptibility testing
作者简介 朱德妹(1945-),女,教授,主要从事新抗菌药物药效学、细菌耐药性和临床重要病原菌基因诊断的研究。通信作者:朱德妹,E—mail:zhu_dm@fudan.edu.cn。
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