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2007年全国CHINET链球菌属分布及耐药性监测 预览 被引量:25

Distribution and antibiotic resistance of Streptococcus spp. : Results of National CHINET Program 2007
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摘要 目的了解全国不同地区12所医院2007年临床分离链球菌属的耐药性。方法收集12所医院2007年度临床分离链球菌属1821株,采用纸片扩散法(K-B法)作药敏试验,并采用CLSI2007年的判断标准。结果1821株链球菌中肺炎链球菌占38.1%(694/1821),β溶血性链球菌占44.0%(802/1821),草绿色链球菌群17.8%(325/1821)。肺炎链球菌中儿童和成人患者青霉素敏感株(PSSP)的检出率分别为11.5%和73.7%,儿童分离株中青霉素不敏感株(PISP和PRSP)的检出率分别为69.2%和19.3%,成人分离株中PISP和PRSP的检出率分别为13.8%和12.6%。802株β溶血性链球菌中A群占61.2%(491/802),B群23.3%(187/802),C、G、F群共占11.2%(90/802)。A及B群对红霉素耐药率高,分别为93.6%和42.9%,其他菌群的耐药率为51.0%~64.7%,5种菌群对青霉素保持较高敏感性。无菌部位草绿色链球菌群对青霉素、红霉素耐药率分别为20.0%和63.3%。未发现对万古霉素、利奈唑胺、替考拉宁耐药的链球菌菌株。结论肺炎链球菌及β溶血链球菌仍是我国常见病原菌,儿童患者肺炎链球菌对青霉素的耐药率高于成人。我国β溶血链球菌对红霉素的耐药率高且存在群间差异。 Objective To investigate the antibiotic resistance of clinical isolates of Streptococcus collected in 2007 CHINET pro gram. Methods A total of 1 821 isolates of Streptococcus were collected from 12 hospitals nationwide in 2007. The susceptibility testing was carried out according to a unified protocol of Kirby Bauer method (KB). Results were analyzed according to CLSI 2007 criteria. Results Among the 1 821 strains of Streptococcus, S. pneumoniae accounted for 38. 1% (694/ 1 821). The β-hemolytic streptococcus isolates accounted for 44.0% (802/1821). The other Streptococcus included S. viridans group (17. 8%). Among the S. pneumoniae isolates, the prevalence of penicillin susceptible strains (PSSP) from children and adults were 11.5% and 73.7%, respectively. The penicillin non-susceptible strain (PISP and PRSP) accounted for 69. 2% and 19.3% in children. The rates of PISP and PRSP in adults were 13.8%and 12.6%. Among the β-hemolytic Streptococcus isolates, Group A type accounted for 61. 2% (491/802), Group B 23. 3% (187/ 802), and Group C, G, F accounted for 11.2% (90/802) totally. The resistance rates of group A and B types to erythromycin were 93. 6% and 42.9%. The resistant rates of other groups of Streptococcus to erythromycin ranged from 51.0% to 64.7%. All five groups were still highly sensitive to penicillin. The resistant rates of S. viridans isolated from sterile sites to penicillin and erythromycin were 20.0% and 63.3%. All isolates were susceptible to vancomycin, linezolid, and teieoplanin. Conclusions S. pneumoniae and β-hemolytic Streptococcus are still the common pathogens in children and adults in China. The prevalence of PNSP (PISP and PRSP) in children is higher than that in adults. The resistant rates of β-hemolytic Streptococcus to erythromycin vary greatly with Streptococcus types. All types of Streptococcus are highly resistant to erythromycin in our country.
作者 王传清 薛建昌 张泓 李万华 徐英春 孙宏莉 胡云建 艾效曼 孙自镛 简翠 倪语星 孙景勇 汪复 胡付品 朱德妹 阮斐怡 俞云松 杨青 卓超 苏丹虹 魏莲花 吴玲 张朝霞 季萍 WANG Chuan-qing, XUE Jian-chang, ZHANG Hong, LI Wan-hua, XU Ying chun, SUN Hong-li, HU Yun-jian, AI Xiao-man, SUN Zi-yong, JIAN Cui, NI Yu-xing, SUN Jing- yong , WANG Fu , HU Fu-pin , ZHU De-reel, RUAN Fei-yi , YU Yun-song , YANG Qing , ZHUO Chao, SU Dan-hong, WEI Lian-hua, WU Ling, ZHANG Zhao-xia, JI Ping. (Children's Hospital of Fudan University, Shanghai 201102, China)
出处 《中国感染与化疗杂志》 CAS 2009年第3期 180-184,共5页 Chinese Journal of Infection and Chemotherapy
关键词 链球菌 耐药性 抗菌药 细菌药敏试验 Streptococcus bacterial resistance antimicrobial agent bacterial susceptibility testing
作者简介 王传清(1967-),女,副教授,医学硕士,主要从事抗感染免疫研究、感染性疾病诊断、细菌耐药性研究。 通信作者:朱德妹,E—mail:zhu_dm@fudan.edu.cn。
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