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PTN、Cyfra21-l和CEA联合检测对肺癌诊断的研究 预览 被引量:8

Comparative study of PTN,Cyfra21-l and CEA test in diagnosis of lung cancer
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摘要 目的:血清PTN与肿瘤关系密切,尤其是PTN与肺癌之间的关系。近来国外关于PTN的研究较多。探讨血清多效蛋白(PTN)、细胞角质蛋白(Cyfra21-l)和癌胚抗原(CEA)单独或联合检测诊断肺癌的价值。方法:选择61例肺癌和17例肺部良性疾病患者,均在治疗前行血清PTN、Cyfra21-l和CEA的检测,比较3种方法单独或联合检测诊断肺癌的价值。结果:血清PTN、Cyfra21-l和CEA联合检测,对肺癌的阳性检出率可达95.08%,与肺良性疾病组比差异有显著性意义(P〈0.05)。结论:血清PTN、Cyfra21-l和CEA联合检测不仅对诊断肺癌价值较高,而且具有互补作用。 Objective: Serum pleiotrophin(PTN) is closely related to tumor,particularly to lung cancer.Many studies focused on PTN recently.This study is to evaluate the diagnostic value of PTN,Cyfra21-l and CEA tests independently or in a combined style in lung cancer.Methods: Sixty-one patients with lung cancer and 17 patients with benign lung lesion disease all received PTN,Cyfra21-l and CEA tests before the treatment.They were compared with pathological results,and then we calculated the diagnostic value of each method and the combined styles.Results: The sensitivity of PTN together with Cyfra21-l and CEA tests is 95.08% and it is the highest among the methods.Conclusion: PTN together with Cyfra21-l and CEA tests has a important diagnostic value through mutual complementation in detecting lung cancer.
作者 钟英 孙建鹰 杜明华 ZHONG Ying,SUN Jian-ying,DU Ming-hua(1.Department of Nuclear Medicine,Zhongda Hospital,Southeast University,Nanjing 210009,Jiangsu,China;2.Chengdu the Sixth People′s Hospital,Chengdu 610051,Sichuan,China)
出处 《医学研究生学报》 CAS 2009年第12期 1281-1283,共3页 journal of Medical Postgraduate yixue yanjiusheng xuebao
基金 江苏省重点技术创新项目(批准号:7625003030) 东南大学国家自然科学基金预研项目(批准号:9290001412)
关键词 肺肿瘤 肿瘤标记物 多效蛋白 Lung cancer Tumor marker Pleiotrophin
作者简介 钟英(1964-),女,黑龙江齐齐哈尔人,主治医师,医学本科,从事核医学专业。 通讯作者:杜明华(1962-),女,新疆乌鲁木齐人,主任医师,医学硕士,从事核医学专业。E-mail:njdmh@yahoo.com.cn
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