Polymer microspheres are stable both chemically and mechanically, whose stabilities are even unaffected by microorganism, acid and base. So they are excellent materials for enzyme immobilization. The designable advantages of the polymer microspheres as the desired support for preparing the immobilized enzyme with high activity and stability, such as regulable composition and functional groups, controllable microsphere size and morphology, structural porosity and high specific surface area, were reviewed. The relation between the structures of the supports and the catalytic activity of immobilized enzyme was surmnarized. Design of ＂tailor-made＂ and effective supports according to the characteristics of enzymes is the development trend in the enzyme immobilization on polymer microsphere in the future. The main applications of immobilized penicillin G acylase and lipase in industrial catalysis were introduced as well.
polymer microsphere support