Objective To compare clinical efficacy and safety between ziprasidone and perphenazine in the treatment of eld- erly schizophrenia. Methods 72 cases of elderly patients with schizophrenia were randomly divided into ziprasidone group and per- phenazine group for 8 weeks. Positive and Negative Syndrome Scale （PANSS） was used to assess the efficacy, side effects scale （TESS） was used to assess adverse reactions. Results After 8 weeks, effective rate of ziprasidone group was 69.44%, with a total effective rate was 88.89% ;perphenazine group were 63.89% and 86.11%, respectively, no statistical difference in therapeutic effect （P 〉 0.05）. However, compared to perphenazine group, adverse reactions of ziprasidone group were much smaller and lighter. Con- clusion Ziprasidone in treatment of elderly schizophrenia is of good efficacy and relatively small adverse reactions.
Internal Medicine of China