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联合测定NSE、CYFRA21-1、CEA和CA125在肺癌诊断中的价值 预览

The Significance of Combined Determination of NSE,CYFRA21-1,CEA and CA125 in the Diagnosis of Lung Cancer
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摘要 目的检测血浆中四项肿瘤标志物的水平,探讨其在肺癌鉴别诊断中的价值。方法测定肺癌和良性肺部疾病患者组血浆中四项肿瘤标志物的水平,采用方差分析进行统计学处理。结果肺癌患者组NSE、CYFRA21-1、CEA和CA125测定值高于肺良性病变组,差异有统计学意义(P〈0.05)。肿瘤标志物测定水平与病理类型有关:血浆NSE水平升高以小细胞肺癌为主;CYFRA21-1以鳞癌为主,而血浆CEA、CA125则以腺癌为主。结论4项肿瘤标志物联合检测有利于肺癌的诊断和鉴别诊断。 Objective To measure the levels of plasma NSE,CYFRA21-1,CEA and CA125 of patients with lung cancer and those with benign lung diseases,and to evaluate the clinical diagnostic value of combined detection of plasma NSE,CYFRA21-1,CEA and CA125 in patients with lung cancer.Methods Plasma NSE,CYFRA21-1,CEA and CA125 levels were determined by chemiluminescence immunoassay in 142 patients with lung cancer,61 patients with benign pulmonary diseases and 60 health controls.The data was analyzed by t test.Results The plasma levels of NSE,CYFRA21-1,CEA and CA125 were significantly higher than that in those with benign lung diseases and health controls.The levels of plasma NSE,CYFRA21-1,CEA and CA125 were related to types of pathology.The highest levels of CEA and CA125 appeared in adenocarcinoma,small cell carcinoma and squamous cell carcinoma,respectively.The highest level of serum NSE appeared in patients with small cell carcinoma.However,the plasma levels of CYFRA21-1 in patients with squamous cell carcinoma were the highest.Conclusion Combined determination of plasma levels of NSE,CYFR21-1,CEA and CA125 is valuable in diagnosis and differential diagnosis of lung cancers.
作者 王俊杰 WANG Jun-jie(.Department of Laboratory,People′s Hospital of Taihe,Anhui,Taihe 236604 )
出处 《临床输血与检验》 2010年第2期 131-133,共3页 Journal of Clinical Transfusion and Laboratory Medicine
关键词 肺癌 肿瘤标志物 NSE CYFRA21-1 CEA CA125 Lung cancer Tumor markers NSE CYFRA21-1 CEA CA125
作者简介 王俊杰(1969-),男,安徽太和人,主管技师,学士,主要从事肿瘤标志物检测工作,(Tel)0558—8696573。
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参考文献8

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