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应用BED-CEIA方法估算江苏省男男性行为人群艾滋病病毒感染的新发感染率 被引量:23

Estimation of HIV-1 incidence of MSM in Jiangsu Province with BED-CEIA assay
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摘要 目的:了解江苏省男男性行为人群(MSM)艾滋病病毒(HIV)的感染状况,估算HIV在该人群中的新发感染率.方法:对2008年国家男男性行为人群艾滋病综合防治试点工作的710份样本,进行HIV-1初筛.复检及确证试验,检出的HIV-1阳性样本,再应用BED HIV-1 IgG捕获酶免疫法(BED-CEIA)检出其中的新发感染样本,进而估算该人群的HIV-1新发感染率.结果:710份样本共检出HIV-1阳性样本40份,HIV-1感染率为5.63%;40份HIV-1阳性样本中的23份被判定为新发感染,感染者中新发感染的比例高达57.5%;校正后的HIV-1新发感染率为7.54%(95% CI:4.46%-10.62%).结论:HIV-1在江苏省MSM人群中的流行已经处于较高水平且新发感染状况不容乐观,必须加大防控力度. Objective:To understand HIV infection of men who have sex with men(MSMs) in Jangsu Province,and estimate the annual HIV incidence of MSMs. Methods:710 samples from national pilot work of HIV/AIDS comprehensive prevention and care among MSMs in 2008 were tested to find HIV-1 seropositive samples.BED HIV-1 IgG capture enzyme immunoassay(BED-CEIA) was used to find recent HIV-1 infections in HIV-1 seropositive samples,and the annual HIV-1 incidence of MSMs was estimated. Results:40 samples were HIV-1 seropositive and the HIV-1 infection incidence was 5.63%. 23 samples were confimrcl to be recently infected,and the recent infection rate was 57.5%. The corrected annual HIV-1 incidence was 7.54%(95% CI:4.46%-10.62%)among MSMs. Conclusion:The HIV-1 infectin in MSMs in Jiangsu Province has entered a period of rapid growth,powerful prevention and control efforts must be performed.
作者 胡海洋 沈圣 还锡萍 闫红静 肖瑶 蒋岩 HU Hai-yang, SHEN Sheng, HUAN Xi-ping, YAN Hong-jing, XIAO Yao, JIANG Yan (1.Section of AIDS/STD Control and Prevention,Jiangsu Center for Disease Control and Prevention,Nanjing 210009;2.National AIDS Reference Laboratory,National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention ,Beijing 100050, China)
出处 《南京医科大学学报:自然科学版》 CAS 北大核心 2010年第4期467-471,共5页 Acta Universitatis Medicinalis Nanjing
基金 江苏省社会发展计划资助项目(BE2009685)
关键词 艾滋病病毒 BED—CEIA 新发感染率 男男性行为人群 HIV BED-CEIA incidence MSMs
作者简介 通讯作者.E-mail:huanxp@vip.sina.com
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