[Objective] To observe the effect of Biqi Capsule on the cartilage histopathologic changes of knee joints in rats with osteoarthritic.[Methods] In Wistar rats,papain was injected into their knee joints to establish the animal model of Osteoarthritis.They were treated with Biqi Capsule（HDG 1.296 g/kg,MDG 0.648 g/kg,LDG 0.324 g/kg） through intragastric administration for six weeks.The cartilage histopathology of knee joint was observed in rat with osteoarthritis.[Results] The extent of edema,degeneration,cluster-like proliferation and necrosis of cartilaginous tissue in treated groups was smaller than those in model group.The accumulated pathology grades of the three treated groups was 41.5,13.5,19 scores respectively.They were lower than that of model groups,which was 57.5 score.The necrosis incidence of chondrocyte in treated groups was 64.%,30%,30% respectively,while it was 70% in model groups.The accumulated pathology grades of the three treated groups were 12.5,6.5,3.5 scores respectively,while it was 29 in the model group,By rank sum test,there was a significant deviation between treated groups（MDG 0.648 g/kg,LDG 0.324 g/kg） and model group（P0.01）.[Conclusion] Biqi Capsule has a protective effect against necrosis of cartilaginous tissue of knee in rats with osteoarthritis.
Tianjin Journal of Traditional Chin Medicine