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白细胞介素-6、降钙素原和C-反应蛋白联合检测在新生儿败血症早期诊断中的价值 被引量:40

Value of Interleukin-6, Procalcitonin and C-reactive Protein in Early Diagnosis of Neonatal Sepsis
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摘要 目的研究白细胞介素-6(IL-6)、降钙素原(PCT)和C-反应蛋白(CRP)在新生儿败血症早期诊断中的应用价值。方法应用酶联免疫(EI。ISA)双抗体夹心法测定血浆IL-6水平,双抗夹心免疫法(ILMA)、免疫比浊法分别测定血浆PCT、CRP水平。结果新生儿败血症组IL-6、PCT和CRP水平急性期分别为(283.54±61.72)ng/L、(13.87士8.54)μg/L和(19.73±9.14)mg/L,恢复期水平分别为(61.50±13.69)ng/L、(0.89土0.33)μg/L和(3.35土2.16)mg/L,正常对照组水平分别为(57.14±10.88)ng/L、(0.77±0.21)μg/L和(2.82±1.83)mg/L,新生儿败血症组IL-6、PCT和CRP水平急性期明显高于恢复期,急性期明显高于正常对照组(P〈0.01);单项检测敏感性和准确性较低,联合二、三项敏感性和准确性较高。结论IL-6、PCT和CRP可作为新生儿败血症快速有效诊断的检测指标,联合二~三项指标有较高的榆出率。 OBJECTIVE To study the value of interleukln-6 (IL-6), procalcitonin (PCT) and C-reactive protein (CRP) in early diagnosis of neonatal sepsis. METHODS IL-6 was determined by ELISA, PCT was determined by ILMA and CRP was determined by nephelometry. RESULTS The levels of IL-6, PCT and CRP in septic acute stage group were (283.54±61.72)ng/L, (13.87±8. 54)μg/L and (19.73±9.14)mg/L. Their levels in septic restoration stage group were (61.50±13.69)ng/L, (0.89±0.33)μg/L and (3.35±2.16)rag/L, and their levels in control group were (57.14±10.88)ng/L, (0.77±0.21)μg/L and (2.82±1.83)mg/L. The levels of IL-6, PCT and CRP in septic acute stage group were significantly higher than those in restoration stage and in control group (P〈0. 01). CONCLUSIONS IL-6, PCT and CRP can be used as rapid diagnostic markers for neonatal sepsis. Combining these tests together would raise the positive rate.
作者 解晶 喻长法 戴卫峰 XIE Jing , YU Chang-fa, DAI Wei-feng (The First People's Hospital of Taizhou, Taizhou, Zhejiang 318020, China)
出处 《中华医院感染学杂志》 CAS CSCD 北大核心 2010年第22期3628-3629,共2页 Chinese Journal of Nosocomiology
关键词 新生儿 败血症 白细胞介素-6 降钙素原 C-反应蛋白 Newborn Sepsis Interleukin-6 Procalcitonin C-reactive protein
作者简介 通讯作者:喻长法,E—mail:yuchangfa123@163.com
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