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辽宁省彰武县农村地区血清脂联素水平与脑卒中关系的病例对照研究 被引量:3

A case-control study on the relationship between serum adiponectin levels and stroke in rural areas of Zhangwu County in Liaoning Province
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摘要 目的探讨农村地区人群血清脂联素(adiponectin,APN)水平及其在脑卒中发病中的作用。方法采用整群随机抽样方法对辽宁省彰武县农村人群进行脑卒中患病情况调查,并从中随机抽取脑卒中患者和健康者各120例进行病例对照研究。结果脑卒中和健康者血清APN水平比较,脑卒中患者血清APN水平(7.414±5.595)mg/L低于对照组(9.471±5.601)mg/L,差异有统计学意义(P〈0.05);脑卒中组和对照组血清APN水平与是否伴高血压有关,单纯脑卒中组、脑卒中合并高血压组与无脑卒中无高血压组相比APN水平下降,差异有统计学意义(P〈0.05),单纯脑卒中组与单纯高血压组相比APN水平下降,差异有统计学意义(P〈0.05),单纯脑卒中组与脑卒中合并高血压组相比APN水平下降,差异有统计学意义(P〈0.05)。脑卒中危险因素的非条件Logistic回归分析显示,血清APN水平下降和收缩型高血压可能是脑卒中的独立危险因素(APN:OR=4.019,95%CI:2.092~7.722;收缩压:OR=3.864,95%CI:2.106~7.087)。血清APN水平影响因素多元逐步回归分析显示,体质指数(BMI)、高密度脂蛋白(HDL)和收缩压(SBP)可能是其水平的影响因素。结论脑卒中患者血清APN水平明显降低,低APN水平可能参与了脑卒中的发病过程;BMI、HDL、SBP可以影响血清APN变化,进而调控脑卒中的发生发展,这为预测脑卒中和评价其预后提供了依据。 Objective To study the association of serum APN level with stroke in rural areas.Methods Using the method of clustering multistage sampling method,the population in rural areas,were investigated for the risk factors of stroke.Using simple random sampling method,Several cases of stroke patients and healthy persons were selected to carry out case-control study.Results The comparison of APN levels between stroke patients and healthy persons showed that APN level was lower in case group than in control group(7.414±5.595 mg/L vs 9.471±5.601 mg/L);APN level was significantly lower in case group without hypertension and case group with hypertension than in control group without hypertension(P0.05);and APN level was significantly lower in case group without hypertension than in control group with hypertension and case group with hypertension(P0.05).Multivariate unconditional Logistic analysis on the related risk factors of stroke showed that lower adiponectin level and systolic hypertension may be independent risk factors of stroke(APN:OR=4.019,95% CI:2.092~7.722;SBP:OR=3.864,95% CI:2.106~7.087).Multivariate linear analysis on the related factors of serum APN level showed that BMI,HDL and SBP were influencing factors of serum APN level.Conclusions APN levels of stroke patients were significantly lower,which may be involved in the pathogenesis of stroke;BMI,HDL, SBP can affect the changes of serum APN,thus control the occurrence and development of stroke,these can provide a basis for predicting and evaluating the prognosis.
作者 王灿 时景璞 付凌雨 王海龙 周波 李辉 腾文禹 董亚珞 董卫 富成国 王文利 WANG Can1,SHI Jing-pu1,FU Ling-yu1,WANG Hai-long1,ZHOU Bo1,LI Hui1,TENG Wen-yu2,DONG Ya-luo1,DONG Wei1,FU Cheng-guo3,WANG Wenli3.1.Department of Clinical Epidemiology,the First Hospital of China Medical University,Shenyang 110001,China;2.Department of Neurology,the First Hospital of China Medical University,Shenyang 110001,China;3.Health Bureau of Zhangwu,Fuxin 123100,China
出处 《中华疾病控制杂志》 CAS 2011年第1期11-14,共4页 Chinese Journal of Disease Control and Prevention
基金 国家自然科学基金(3067179630800944) 辽宁省科技厅基金(2005225010-2)
关键词 脂联素 脑卒中 危险因素 Adiponectin Stroke Risk factors
作者简介 王灿(1983-),女,山东济宁人,医师,硕士。主要研究方向:临床流行病学。 【通讯作者】时景璞,E-mail:sjp56@yahoo.com
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