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ERK1/2在胶质瘤中的表达及意义

Expression and clinical significance of ERK1/2 in human glioma
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摘要 目的探讨细胞外信号调节激酶1/2(ERK1/2)在人脑胶质瘤中的表达及其与胶质瘤的发生发展的关系。方法收集具有明确病理分级的胶质瘤标本48例,WHOⅠ~Ⅱ级15例,Ⅲ级21例,Ⅳ级12例;另取8例正常脑组织作正常对照。用免疫组织化学染色检测ERK1/2和磷酸化ERK1/2(p-ERK1/2)表达水平。结果在胶质瘤组织中,ERK1/2和p-ERK1/2表达均增高,且与胶质瘤恶性程度呈正相关;在Ⅲ、Ⅳ级胶质瘤中,ERK1/2和p-ERK1/2表达水平显著强于Ⅰ、Ⅱ级胶质瘤。结论 ERK1/2在胶质瘤组织中表达水平与胶质瘤的恶性程度有关。 Objective To investigate the expression of and clinical significance of extracellular signal-regulated protein kinase 1/2(ERK1/2) in human glioma.Methods The expressions of ERK1/2 and phosphorylation of ERK1/2(p-ERK1/2) were dectected by immunohistochemistry method in 48 patients with glioma(grade Ⅰ~Ⅱ 15 cases,Ⅲ 21 cases,Ⅳ 12 cases) and 8 normal brain tissues.Results ERK1/2 and p-ERK1/2 were highly expressed in glioma,which was positively correlated with advancing pathological grades.The expressions of ERK1/2 and p-ERK1/2 were higher in higher grade astrocytomas(grade Ⅲ and Ⅳ) than those in lower grade astrocytomas(grade Ⅰ and Ⅱ).Conclusion The expressions of ERK1/2 and p-ERK1/2 are correlated with malignancy of glioma.
作者 汪晶 李民 陈云祥 程刚 尤永平 耿晓增 WANG Jing,LI Min,CHEN Yunxiang,et al.Department of Neurosurgery,First Affiliated Hospital,Nanjing Medical University,Nanjing 210029, CHINA
出处 《江苏医药》 CAS CSCD 北大核心 2011年第6期694-696,共3页 Jiangsu Medical Journal
关键词 胶质瘤 细胞外信号调节激酶1/2 Glioma Extracellular signal-regulated protein kinase 1/2
作者简介 责任作者:耿晓增E-mail:gengxiaozeng@yahoo.com.cn
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