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宁嗽露中盐酸麻黄碱的含量测定 预览 被引量:1

Determination of ephedrina hydrochloridum in Ningsoulu
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摘要 目的建立高效液相色谱法测定宁嗽露中盐酸麻黄碱的含量。方法采用反相高效液相色谱法,C18色谱柱,流动相为醋酸铵缓冲液-甲醇-乙腈(94:1:5),检测波长为257 nm,流速为1.0 mL.min-1,柱温40℃。结果盐酸麻黄碱浓度在0.058~0.58 mg.mL-1范围内浓度与峰面积呈良好的线性关系(r=0.999 2),该制剂中盐酸麻黄碱的平均回收率为99.12%,RSD为0.92%(n=5)。结论该方法简便、准确、可靠,可用于宁嗽露中盐酸麻黄碱的含量测定。 Objective To establish an HPLC method to determine ephedrine hydrochloride in Ningsoulu.Methods The assay wavelength was carried out on ODS C18 column with ammonium acetate buffer solution-methanol-acetonitrile(94:1:5) as mobile phase.The detection wavelength was 257 nm.The flow rate was 1.0 mL·min-1 and column temperature was 40 ℃.Results The linear range of ephedrine hydrochloride was 0.058~0.58 mg·mL-1(r=0.999 2).The average recovery was 99.12% with RSD 0.92%(n=5).Conclusion This method was convenient,reliable and accurate,it can be used for the determination of ephedrine hydrochloride in Ningsoulu.
作者 解玲 范秀玉 JIE Ling,FAN Xiu-yu (1.Shandong Drug and Food Vocational College,Weihai 264210,China;2.Shandong Lvye Pharmaceutical Co.,Ltd.,Yantai 264004,China)
出处 《齐鲁药事》 2011年第4期 213-215,共3页 qilu pharmaceutical affairs
关键词 盐酸麻黄碱 高效液相色谱 宁嗽露 Ephedrine hydrochloride HPLC Ningsoulu
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