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静脉输注右美托嘧啶抑制芬太尼引起的呛咳 被引量:8

The Irritation and Cough Causing by Intravenous Infusion of Dexmedetomidine for Inhibition to Fentanyl
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摘要 目的观察预先输注右美托嘧啶能否抑制芬太尼引起的呛咳。方法 60例患者被随机分为右美托嘧啶组和安慰剂组,每组30例。右美托嘧啶组患者输注右美托嘧啶;安慰剂组输注生理盐水。在给予负荷剂量的药物后,静脉给予芬太尼。结果双盲观察记录注射芬太尼后2分钟内患者出现呛咳,并评价呛咳的程度。右美托嘧啶组患者呛咳的发生率明显低于安慰剂组(23.3%对56.7%,P〈0.01),患者发生呛咳的程度也低于安慰剂组。结论预先输注右美托嘧啶(1ug/kg)能够有效抑制芬太尼引起的呛咳。 Objective To observe whether if infuse Dexmedetomidine in advance can inhibit irritation and cough casing by Fentanyl.Methods 60 patients were separated randomly to dexmedetomidine group(GE) and placebo group(PG),each group had 30 patients.Patients in GE infused dexmedetomidine;patients in PG infused saline.Both of them were infuse fentanyl after taking drugs of load dosage.Results Patients appeared irritation and cough within 2 minute after infusing fentanyl by double-blind observation record.The degree of irritation and cough were evaluated.The incidence rate of irritation and cough of patients in GE was obvious lower than in PG(23.3% TO 56.7%,p0.01),the degree of it also was lower than PG.Conclusions To infuse dexmedetomidine(lug/kg) in advance can effectively inhabit the irritation and cough causing by fentanyl.
作者 袁宏勋 顾科 王保国 Yuan Hongxun,Gu Ke,Wang Baoguo No.Eleventh Clinical Medical College of Capital Medical University,Anesthesia Department of Beijing Sanbo Brain Hospital,Beijing 100093,China
出处 《中国病案》 2011年第5期 63-64,共2页 Chinese Medical Record
关键词 右美托嘧啶 芬太尼引起的呛咳 Dexmedetomidine Irritation and cough causing by fentanyl
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