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急性胰腺炎患者某些细胞因子改变的临床意义 被引量:11

Clinical significance of serum cytokines determination in patients with acute pancreatitis
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摘要 目的:探讨细胞因子在急性胰腺炎中的变化及其临床意义。方法:检测了42例急性胰为患者血清肿瘤坏死因子(TNF)、白细胞介素6(IL-6)及C-反应蛋白(CRP)。结果:所有胰腺炎患者在入院第1、4天,血甭肿瘤坏死因子、白细胞介素6均明显升高,尤其是重型患者,升高更为明显。CRP在入院第1天无明显升高,第4天时升高显著。结论:肿瘤坏死因子。白细胞介素6、C-反应蛋白第三种细胞因子参与了急性胰腺炎的发病 Objective:To study the clinical significance of serum cytokines in patients with acute pancreatitis(AP).Methods:Tumor necrosis factor(TNF α),interleukin 6(IL 6),and C reactive protein(CRP) levels were determined in 42 patients with AP.Results:On the 1st and 4th days after admission all patients with AP and especialy in the severe cases,TNF α、IL 6 levels were elevated significantly than that in normal controls,but the level of C reactive protein did not change on the lst day,It was elevated only following the increasment of TNF α、IL 6 on the 4th day.Conclusion:Cytokines are involved in the pathogenesis of AP.Measurement of serum TNF α、IL 6、CRP levels may be taken as useful markers to diagnose and the prognosis of AP.
作者 周力 董穗生 Zhou Li,Dong Suisheng,Tan Qinghua,et al.The Affiliated Hospital of Guiyang Medical College,Guiyang 550004.
出处 《急诊医学》 CSCD 1999年第5期 314-315,共2页
关键词 急性 胰腺炎 细胞因子 肿瘤坏死因子 Acute pancreatitis Cytokine
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