Objective To evaluate the effect of preoperative and postoperative use of celecoxib, a kind of selective cyclooxygenase 2 （ COX 2） inhibitor, on postoperative pain after artificial total knee replacement（TKA）, and observe its safety and effectiveness in decreasing the postoperative use of opiate drugs. Methods Thirty patients undergwent selective knee replacement were randomly given oral celecoxib 200 mg（ group CE, n = 15 ） or placebo （ group E, n = 15 ） 1 hour prior to surgery. All patient - controlled epidural analgesia after surgery for 72 h （0.1 mg/ml morphine ＋ 1.2 mg/ml bupivacaine ＋ 0.02 mg/ml droperidol）. Modified verbal rate scale was used to evaluate postoperative pain intensity, the outcomes included pain scores during rest and analgesia satisfaction. Daily morphine consumption was recorded. Results The pain scores were significantly less in the group CE than in group E during rest and knee joints movement on the first and second postoperative day. Analgesic satisfaction increased in group CE after-24 h（100% ）, above 60% of group E（χ2 =6.71, P 〈0.01）, two groups of patients was no significant difference in adverse reactions. Conclusions Celecoxib increases analgesia satisfaction, reduces pethidine hydrochloride and pain after TKA.
Chinese Journal of Practical Medicine