[Objective]To observe the availability and safety of dexmedetomidine combined sevoflurane in deliberate hypotension for nasal endoscopic surgery. [Methods] Forty ASA I-Ⅱ patients undergoing nasal endoscopic surgery were randomly divided into two groups. Group I （ n = 20） was given dexmedetomidine combined sevoflurane for deliberate hypotension and group Ⅱ（ n = 20） was anesthetized with sevoflurane. Midazolam, cisatracurium besylate, fentanyl and etomidate were used for the anesthesia induction of two groups. After the start of surgery, in group Ⅰ 1%-2% sevoflurane was inhaled and dexmedetomidine was infused into micro pump to maintain mean arterial pressure（MAP） around 65mmHg. In group Ⅰ, 1% -3% sevoflurane was inhaled and blood pressure was maintained at the base level before operation. In two groups, propofol was infused into micro pump, and fentanyl and cisatracurium besylate were intravenously injected at interval to maintain the anesthesia. Blood loss, operation time, MAP and heart rate（HR） before anesthesia（T1）, 10min after operation（Tz）, 60min after operation （Ta） and the immediate after extubation（T4） were observed. [Resuits] Blood loss and operation time in group I were significantly less than those in group Ⅰ （ P〈0.05）. The MAP and HR in group I during operation were significantly lower than those before operation（ P〈0.05）.. [Conclusion] Dexmedetomidine combined with sevoflurane in deliberate hypotension for nasal endoscopic surgery can effectively reduce blood loss, improve the operating field and shorten the operation time.
Journal of Clinical Research