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卵巢癌患者血清组织激肽释放酶11检测及意义

Clinical significance of serum human kailikrein 11 in patients with ovarian cancer
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摘要 目的探讨卵巢癌患者血清组织激肽释放酶11(KLK11)检测的临床价值。方法用ELISA法测定30例卵巢癌患者、26例卵巢良性肿瘤患者及32例健康妇女血清中KLK11水平并以健康对照组95%可信区间的上限值为阳性标准,分析KLK11在三组之间阳性率差异。结果卵巢癌患者血清KLK11阳性率(73.3%)显著高于卵巢良性肿瘤组(7.7%)和健康对照组(6.3%)(均P〈0.01),而卵巢良性肿瘤组和健康对照组之间差异无统计学意义(P〉0.05)。结论血清KLK11是一种新的卵巢癌肿瘤标志物,对卵巢癌的诊断有较高的临床价值。 Objective To investigate the diagnostic and prognostic significance of serum human kallikreinll ( KLK11 ) in patients with ovarian cancer. Methods The level of serum KLK11 was determined by enzyme-linked immunoassay(ELISA) for 30 patients with ovarian cancer, 26 patients with benign gynecologic processes and 32 healthy subjects,and the KLKll value beyond the upper-limit of 95% credibility interval( 95% CI) based on the health controls was used as the positive value. The positive rate of KLK11 was compared among the three groups. Results The positive rate of KLK11 in patients with ovarian cancer was significantly higher than those in patients with benign gynecologic processes or in healthy subjects[ (73.3%) and(7.7% ) or(6.3% ) , all P 〈 0.01 ) ], and there was no significant difference between ovarian benign tumor group and the healthy control group ( P 〉 0.05 ). Conclusion The serum KLK11 should be a novel tumor marker in the clinical diagnosis of ovarian cancer.
作者 宋世军 张旋 SONG Shi-jun, ZHANG Xuan. Department of Clinical Laboratory, The Maternal and Child Health Hospital of Longgang District,Shenzhen , Guangdong 518172, China
出处 《中国基层医药》 CAS 2011年第15期2020-2021,共2页 Chinese Journal of Primary Medicine and Pharmacy
基金 广东省深圳市科技局资助项目(200903231)
关键词 卵巢肿瘤 组织激肽释放酶类 Ovarian neoplasms Tissue kallikrein
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