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右美托咪啶辅助麻醉下肺癌根治术病人麻醉后寒战的发生 被引量:16

Incidence of postanesthetic shivering in patients undergoing radical operation for lung cancer under dexmedetomidine-assisted anesthesia
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摘要 目的评价右美托眯啶辅助麻醉下肺癌根治术病人麻醉后寒战的发生。方法择期全麻复合硬膜外麻醉下开胸行肺癌根治术病人80例,性别不限,年龄50~75岁,身高158~180cm,体重48.79kg,ASA分级Ⅰ或Ⅱ级,采用随机分层法,将病人随机分为2组(n=40):生理盐水对照组(C组)和右美托咪啶组(D组)。2组麻醉诱导及维持方法相同。静脉注射咪达唑仑、芬太尼、异丙酚和罗库溴铵进行麻醉诱导,气管插管后机械通气。麻醉维持:吸人七氟醚,间断硬膜外注射罗哌卡因,维持BIS值40—55。D组气管插管后静脉输注右美托咪啶0.5μg·kg-1·h-1至手术结束前1h,C组给予等容量生理盐水。记录术后1h内寒战发生情况。结果C组和D组寒战发生率分别为50%和10%;与C组比较,D组寒战发生率降低,寒战程度减轻(P〈0.05)。结论右美托咪啶辅助麻醉可降低肺癌根治术病人麻醉后寒战的发生机率。 Objective To evaluate the incidence of postanesthetic shivering in patients undergoing radical operation for lung cancer under dexmedetomidine-assisted anesthesia. Methods Eighty ASA Ⅰ or Ⅱpatients, aged 50-75 yr, height 158-180 cm, weighing 48-79 kg, scheduled for radical operation for lung cancer under general anesthesia combined with epidural anesthesia, were randomly divided into 2 groups ( n = 40 each) : normal saline control group (group C) and dexmedetomidine group( group D). Anesthesia was induced with midazolam, fen- , propofol and rocuronium. The patients were tracheal intubated and mechanically ventilated. Anesthesia was maintained with sevoflurane inhalation and intermittent epidural ropivacaine. BIS was maintained at 40-55. Group D received dexmedetomidine intravenous infusion at 0.5 μg·kg-1·h-1 from immediately after tracheal intubation until 1 h before the end of operation, and group C received the equal volume of normal saline. The shivering within 1 h after operation was scored and recorded. Results The incidence rate of postanesthetic shivering was 50% in group C and 10% in group D. Compared with group C, the incidence rate and degree of shivering were decreased in group D( P 〈 0.05). Conclusion Dexmedetomidine-assistcd anesthesia can reduce the incidence of postanesthetic shivering in patients undergoing radical operation for lung cancer.
作者 陈忠华 蒋宗明 陈念平 郑羡河 张昌锋 胡双燕 CHEN Zhong-hua , JIANG Zong-ming , CHEN Nian-ping , ZHENG Xian-he , ZHANG Chang-feng, HU Shuang-yan. Department of Anesthesiology, Shaoxing People's Hospital, Shaoxing 312000, Zhejiang Province, China
出处 《中华麻醉学杂志》 CAS CSCD 北大核心 2011年第10期1217-1219,共3页 Chinese Journal of Anesthesilolgy
关键词 右美托咪啶 寒战 麻醉 手术后并发症 Dexmedetomidine Shivering Anesthesia Postoperative complications
作者简介 通信作者:陈忠华,Email:Qcma@zeldawear.com
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参考文献8

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二级参考文献15

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