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ICAM-1和VCAM-1在糖尿病视网膜病变中的作用 预览 被引量:4

The role of ICAM-1 and VCAM-1 in diabetic retinopathy
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摘要 糖尿病会造成视网膜很多异常改变,其中包括细胞间粘附分子-1(intercellular adhesion molecule-1,ICAM-1)和血管细胞粘附分子-1(vascular cell adhesion molecule-1,VCAM-1)的上调,这显示了炎症反应在糖尿病视网膜病变(diabetic retinopathy,DR)发展中发挥了一些作用。本文针对粘附分子ICAM-1和VCAM-1在DR的血管内皮细胞的损伤及其在炎症反应中发挥的重要作用进行了简要分析。 Diabetes causes a lot of abnormalities in the retina including up-regulation of intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1),and these changes suggest a role for inflammation in the development of diabetic retinopathy(DR).In this paper,we analyzed the important role of ICAM-1 and VCAM-1 on the damage of vascular endothelial cells and the inflammatory response in DR briefly.
作者 李春深 苗戎 蔡青 周涛 谭俊珍 武学润 常柏 Chun-Shen Li 1,Rong Miao1,Qing Cai1,Tao Zhou1,Jun-Zhen Tan1,Xue-Run Wu1,Bai Chang2 1Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 2Metabolic Disease Hospital of Tianjin Medical University,Tianjin 300070,China
出处 《国际眼科杂志》 CAS 2012年第1期 1-3,共3页 International Journal of Ophthalmology
基金 中国国家自然科学基金资助项目(No.30973753)
关键词 糖尿病性视网膜病变 细胞间粘附分子-1 血管细胞粘附分子-1 炎症反应 diabetic retinopathy intercellular adhesion molecule-1 vascular cell adhesion molecule-1 inflammatory response
作者简介 李春深,医学博士,研究方向:中西医结合治疗内分泌及代谢病。 常柏,博士,副主任医师,研究方向:糖尿病及并发症的临床及基础研究.changbai1972@126.com
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同被引文献60

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