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Angioarchitecture and CD133~+ tumor stem cell distribution in intracranial hemangiopericytoma A comparative study with meningioma 预览

Angioarchitecture and CD133+ tumor stem cell distribution in intracranial hemangiopericytoma --- A comparative study with menmgioma
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摘要 Angioarchitecture plays an important role in the malignant development of intracranial hemangioperi-cytoma. It remains poorly understood whether high frequency of hemorrhage during clinical surgery for intracranial hemangiopericytoma is associated with angioarchitecture. The present study utilized he-matoxylin-eosin staining, and immunohistochemical staining with epithelial membrane antigen, vimentin, CD34, von Willebrand factor (vWF) and CD133 to observe characteristics of angioarchitec-ture. In addition, silver stains were used to demonstrate changes in reticular fibers in the wall of vessel channels in intracranial hemangiopericytoma and meningioma. Five patterns of angioarchitecture were identified in intracranial hemangiopericytoma, namely tumor cell islands, vasculogenic mimicry, mosaic blood vessels, sprouting angiogenesis, and intussusceptive angiogenesis. Several CD133+ tumor cells were found to form tumor cell islands. A connection between vWF + and vWF- channels was detected in the pattern of intussusceptive angiogenesis, and some vimentin+ tumor cells were embedded in the periodic acid-Schiff positive channel wall. Incomplete threads of reticular fibers formed the walls of larger pseudo-vascular channels and some tumor clumps or scattered tumor cells were detected 'floating' in them. The angioarchitecture, specific markers and reticular fibers of intracranial hemangiopericytoma were significantly different from meningioma. Angioarchitecture provides a functional vascular network for vascular evolution in intracranial hemangiopericytoma and contributes to significant intra-operative bleeding. Angioarchitecture plays an important role in the malignant development of intracranial hemangiopericytoma. It remains poorly understood whether high frequency of hemorrhage during clinical surgery for intracranial hemangiopericytoma is associated with angioarchitecture. The present study utilized hematoxylin-eosin staining, and immunohistochemical staining with epithelial membrane antigen, vimentin, CD34, von Willebrand factor (vWF) and CD133 to observe characteristics of angioarchitecture. In addition, silver stains were used to demonstrate changes in reticular fibers in the wall of vessel channels in intracranial hemangiopericytoma and meningioma. Five patterns of angioarchitecture were identified in intracranial hemangiopericytoma, namely tumor cell islands, vasculogenic mimicry, mosaic blood vessels, sprouting angiogenesis, and intussusceptive angiogenesis. Several CD133+ tumor cells were found to form tumor cell islands. A connection between vWF ^+ and vWF channels was detected in the pattern of intussusceptive angiogenesis, and some vimentin^+ tumor cells were embedded in the periodic acid-Schiff positive channel wall. Incomplete threads of reticular fibers formed the walls of larger pseudo-vascular channels and some tumor clumps or scattered tumor cells were detected "floating" in them. The angioarchitecture, specific markers and reticular fibers of intracranial hemangiopericytoma were significantly different from meningioma. Angioarchitecture provides a functional vascular network for vascular evolution in intracranial hemangiopericytoma and contributes to significant intra-operative bleeding.
作者 Zhongguo Zhang Mingguang Zhao Zaihua Xu Zhenquan Song Zhongguo Zhang2, Mingguang Zhao1, Zaihua Xu1, Zhenquan Song1 1Department of Neurosurgery, Northern Hospital, Shenyang 110840, Liaoning Province, China 2Surgical Department of Colorectal Cancer, Liaoning Provincial Cancer Hospital, Shenyang 110042, Liaoning Province, China
出处 《中国神经再生研究:英文版》 SCIE CAS CSCD 2011年第34期 2687-2693,共7页 Neural Regeneration Research
基金 Acknowledgements: We thank Xueying Yang for language editing, Xinii Feng, Youli Chen and Yuanyuan Huang, Department of Neurosurgery, the Northern Hospital for technical support.
关键词 血管构筑 细胞分布 肿瘤细胞 外皮 血管性血友病因子 免疫组化染色 网状纤维 血管生成 intracranial hemangiopericytoma angioarchitecture tumor cell islands vasculogenic mimicry mosaic blood vessels, sprouting angiogenesis intussusceptive angiogenesis meningioma CD133
作者简介 Zhongguo Zhang, Doctor, Associate chief physician, Surgical Department of Colorectal Cancer, Liaoning Provincial Cancer Hespitar, Shenyang 110042, Liaoning Province, China Corresponding author: Mingguang Zhao, Doctor, Associate chief physician, Department of Neurosurgery, Northern Hospital, Shenyang 110840, Liaoning Province, China zhaomingguang 1972 @ hotmail.com
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