期刊文献+

297例维生素类药物不良反应分析 预览 被引量:5

Analysis of 297 cases of ADRs induced by Vitamins
在线阅读 下载PDF
分享 导出
摘要 目的探讨维生素类药物致不良反应的一般规律及特点,以提高临床用药的安全性。方法通过检索中国期刊全文数据库1994年1月~2011年8月间相关期刊文章,收集维生素类药物不良反应报道,并进行分类统计、分析。结果维生素类药物所致不良反应共297例,维生素K1所占比例最大(48.8%),临床表现主要为全身性损害、皮肤及其附件损害,严重者可出现过敏性休克,不良反应多发生在用药30 min内,且静脉给药途径致不良反应所占比例大。结论临床应用维生素类药物应严格掌握用量与疗程,在充分了解该类药物所致不良反应的规律与特点之后,加强临床用药监测,以确保药物治疗全过程安全、合理、有效。 Objective To discuss the characteristics and regularity of adverse drug reaction(ADR) induced by Vitamins,in order to improve the safety of clinical medication.Methods Literatures of ADR induced by Vitamins were retrieved from CNKI during the period of January 1994 to August 2011,and then analyzed statistically.Results Totally 297 cases of ADR induced by Vitamins were collected,of which Vitamin K1 was occupied the largest proportion,accounted for 48.8%.The clinical manifestations were mainly systemic damage and skin and its appendages injuries,and the most severe reaction was anaphylactic shock.Most ADR occurred within 30 min.Intravenous administration was the commonest routes of administration resulted in ADR.Conclusion Clinical staff should grasp the rational dosage and course of Vitamins strictly.Monitoring of the use of drugs should be strengthened to ensure rational,safe and effective use of Vitamins.
作者 朱金平 陈春枚 费燕 ZHU Jinping CHEN Chunmei FEI Yan Department of Pharmacy,the 175th Hospital of PLA The Affiliated Southeast Hospital of Xiamen University,Fujian Province,Zhangzhou 363000,China
出处 《中国医药导报》 2012年第9期 109-111,共3页 China Medical Herald
关键词 维生素 不良反应 文献分析 合理用药 Vitamins Adverse drug reaction Literature analysis Rational use of drug
作者简介 朱金平(1986.10-),女,本科,药师;研究方向:临床药学。 [通讯作者]费燕(1980.7-),女,硕士,主管药师,研究方向:临床药学与药物分析。
  • 相关文献

参考文献7

二级参考文献25

  • 1LILX XIONGJY.The Analysis ADRs Induced by Chinese Material Medica Injections.天津护理,2004,12(3):168-169. 被引量:1
  • 2ZHAOBH.ADRs Induced by Chinese Material Medica Preparation: Analysis of 87 Cases.中国药房,2007,18(18):1418-1419. 被引量:1
  • 3FANGSQ.Inspiration of british yellow card system on monitoring adverse drug reactions in China .国际医药卫生导报,2002,12(23):100-102. 被引量:1
  • 4SFDA has published the information of adverse drug reaction's moni- toring in 2009[ EB/OL]. http: //www. cnr. on/ allnews/201004 / t20100422-506323538. html, 2010-04-22. 被引量:1
  • 5Fraunfelder FW, Fraunfelder FT, Illingworth DR. Adverse ocular effects associated with niacin therapy [J]. Br J Ophthalmol, 1995, 79:54-56 被引量:1
  • 6Parry GJ, Bredesen DE. Sensory neuropathy with low dose pyridoxine [J]. Neurology, 1985, 35:1466-1468 被引量:1
  • 7Brush MG. Clinical and physiological applications of B-6[M]. New York: Alan R.Liss, 1988.363-379 被引量:1
  • 8Dalton K, Dalton MJT. Characteristics of pyridoxine overdose neuropathy syndrome [J]. Acta Neurol Scand, 1987, 76:8-11 被引量:1
  • 9Berlin H, Berlin R, Brante G. Oral treatment of pernicious anemia with high doses of vitamin B 12 without intrinsic factor [J]. Acta Med Scand, 1968, 184:258-274 被引量:1
  • 10Juhlin L, Olsson MJ. Improvement of vitiligo after oral treatment with vitamin B12 and folic acid and the importance of sun exposure [J]. Acta Derm Venereol, 1997, 77:460-462 被引量:1

共引文献36

同被引文献41

引证文献5

二级引证文献19

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈