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脑血栓形成过程中血液流变性的变化分析 预览 被引量:9

Analysis of blood rheology change in the process of cerebral thrombosis
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摘要 目的观察脑血栓形成过程中血液流变性的变化,为脑疾病的诊断与预防提供参考。方法分别检测脑癌组(n=60)、脑梗死组(n=40)、缺血性脑血管病组(n=30)与健康对照组(n=60)个体的血液流变学指标,包括凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、血小板(PLT)计数、纤维蛋白原(FIB)、蛋白C(PC)及纤溶酶原激活物抑制剂(PAI-1)等。结果脑癌组的APTT、PT、TT与健康对照组相比无统计学差异(P〉0.05),但脑梗死组与缺血性脑血管病组的APTT、PT、TT较对照组明显延长,差异有统计学意义(P〈0.05)。缺血性脑血管病组、脑梗死组和脑癌组的PLT均低于对照组,但脑癌组高于脑梗死组,差异有统计学意义(P〈0.05)。缺血性脑血管病组、脑梗死组的FIB低于对照组;缺血性脑血管病组和脑梗死组之间也有统计学差异(P〈0.05)。缺血性脑血管病组、脑梗死组和脑癌组血浆PC活性均低于对照组,但脑癌组高于脑梗死组,差异有统计学意义(P〈0.05)。脑梗死组和脑癌组的PAI-1活性均高于对照组和缺血性脑血管病组,差异有统计学意义(P〈0.05)。结论脑血栓形成的过程中,缺血性脑血管病、脑梗死和脑癌患者在凝血、抗凝和血小板功能及血栓前状态的表现存在差异,血液流变学的相关分子标记可作为监测脑癌早期血栓形成高危状态的指标。 Objective To study blood rheology changes during the development of cerebral thrombosis in order to provide a reference for brain disease diagnosis and prevention.Methods Patients with brain cancers(n=60),cerebral infarction(n=40),ischemic cerebrovascular disease(n=30)and healthy controls(n=60)were tested for hemorheology indices including activated partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),platelet(PLT)counting,fibrinogen(FIB),protein C(PC)and plasminogen activator inhibitor-1(PAI-1).Results No significant difference in APTT,PT,TT between brain cancer group and healthy controls was found(P〈0.05).However,APTT,PT and TT of the cerebral infarction group and ischemic cerebrovascular disease group were significantly greater than those of control group(P〈0.05).PLT of ischemic cerebrovascular disease group,cerebral infarction group and brain cancer group was lower than that of the control group,but was significantly higher in brain cancer group than in cerebral infarction group(P〈0.05).FIB of ischemic cerebrovascular disease group and cerebral infarction group was lower than that of the control group,and there was also significant difference between ischemic cerebrovascular disease group and cerebral infarction group(P〈0.05).Plasma PC activity of ischemic cerebrovascular disease group,cerebral infarction group and brain cancer group was lower than of the control group,but was significantly higher in brain cancer group than cerebral infarction group(P〈0.05).PAI-1 of cerebral infarction group and brain cancer group was significantly higher than that of the control group and ischemic cerebrovascular disease group(P〈0.05).Conclusion Significant differences exist in terms of blood coagulation,anticoagulation,platelet function and prethrombotic status in the development of cerebral thrombosis in ischemic cerebrovascular disease,cerebral infarction and brain cancer patients.Therefore,blood rheology related molecular
作者 吴刚 夏修良 WU Gang,XIA Xiu-liang(Department of Neurology,People's Hospital,Binzhou 256610,China)
出处 《成都医学院学报》 CAS 2012年第1期 75-77,共3页
基金 中国高校医学期刊临床专项资金项目(NO11221506)
关键词 脑血栓形成 血液流变学 凝血 血小板 Cerebral thrombosis Blood rheology Blood coagulation Platelet
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