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热疗配合腹腔灌注化疗治疗恶性腹腔积液的临床观察 预览

Clinical Observation of Hyperthermia combined with Intraperitoneai Chemotherapy in the Treatment of Malignant Ascites
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摘要 目的:探讨热疗联合腹腔灌注化疗治疗恶性腹腔积液的临床疗效和不良反应。方法:将恶性腹腔积液患者58例分为两组,腹腔灌注化疗同时配合热疗组(治疗组)30例,单纯腹腔灌注化疗组(对照组)28例。评估疗效及不良反应。结果:腹腔积液疗效评价:治疗组有效率为86.7%(26/30),对照组有效率57.2%(16/28),两组差异有统计学意义(P=0.012);生活质量评价:治疗组改善96.7%(29/30),对照组改善71.4%(20/28),两组差异有统计学意义(P=0.008)。两组的不良反应发生率差异无统计学意义(P〉0.05)。结论:热疗加局部腹腔灌注化疗治疗恶性腹腔积液疗效肯定,不良反应轻微,值得临床推广。 Objective: To investigate the clinical efficacy and adverse reactions of hyperthermia combined with intraperitoneal chemotherapy in the reatment of malignant aseites. Methods : Fifty-eight patients with malignant ascites were divided into two groups : 30 patients in intraperitoneal chemotherapy combined with hyperthermia group (treatment group) and 28 patients in intrapefitoneal chemotherapy group( control group). The efficacy and adverse reactions were assessed. Results: Clinical evaluation of ascites: the ef- ficacy was 86. 7% (26/30)in the treatment group and 57.2% ( 16/28 )in the control group with statistical difference( P = 0. 012 ). The quality of Life was improved up to 96. 7 % (29/30) in the treatment group, while 71.4% (20/28) in the control with significant differ- ence(P =0. 008). No significant difference was observed of the adverse reactions between the two groups( P 〉 0. 05 ). Conclusion: Intraperitoneal chemotherapy combined with local hyperthermia for the treatment of malignant aseites is effective with mild adverse reac- tions. It is worthy of clinical promotion.
作者 任培蓉 吴敬波 叶华 REN Pei-rong ,WU Jing-bo,YE Hua ( The Department of Oncology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China)
出处 《肿瘤预防与治疗》 2012年第3期 172-174,183,共4页 Sichuan Journal of Cancer Control
关键词 热疗 腹腔灌注化疗 恶性腹腔积液 Hyperthermia Intraperitoneal Chemotherapy Malignant Ascites
作者简介 任培蓉(1972-),女,四川宜宾人,大学本科,主治医师,主要从事肿瘤内科和放射治疗工作。
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