Objective To explore the correlations among the serum level of homocysteine, P300 and symptoms. Methods P300 were obtained from 68 firstepisode asymptomatic cerebral infarction （ACI） and 62 health controls （HC）, the serum level of homocysteine was measured by enzyme-linked immunosorbent assay, and Clinical symptoms were assessed with Montreal Cognitive Assessment （Mo- CA） Scale and Mini-Mental State Examination（MMSE） at the same time. Results The serum level of homocysteine was significantly higher in ACI group than in HC group （P 〈 0.01）, Compared with HC group, P300 latency was significantly prolonged and P300 amplitude significantly decreased. The serum level of homocysteine in ACI group was negatively correlated with P300 amplitudes, but positively correlated with the latency. The serum level of homocysteine in ACI group was negatively correlated with the score of MoCA scale and no correlated with the score of MMSE scale. The score of MoCA scale was negatively correlated with P300 amplitudes, but positively correlated with the latency,no correlated with the score of MMSE scale. The serum level of homocysteine decreased significantly and no significant change in P300 latency, amplitude after treatment by Folic acid and Vitamin B12 for. eight weeks in ACI group. The P300 amplitude was increased significantly （P ; 0.01） and no significantly change in P300 latency and the score of MoCA scale after twelve week treatment （P 〉 0.05）. Conclusions The serum level of homocysteine in the first-episode ACI was increased, and cognitive dysfunctions may be related to high serum level of homocysteine. The treatment with Folio acid and Vitamin B12 might improve cognitive function in ACI patients. P300 and MoCA Scale were sensitive index for evaluation of cognitive function.
Nervous Diseases and Mental Health
Asymptomatic cerebral infarction （ACI）
Cognitive function Event--related potentials, P300