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高原地区房间隔缺损合并肺动脉高压的调查分析 被引量:4

Risk factors of pulmonary arterial hypertension in patients with atrial septal defect at high altitude area
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摘要 目的了解高原地区房间隔缺损(ASD)患者合并肺动脉高压(PAH)的发生情况及PAH的危险因素。方法回顾性分析2007年1月至2009年12月3年收治的海拔2000m以上地区526例单纯ASD患者的临床资料。以二分类logistic回归分析ASD合并PAH的危险因素,并分析PAH与年龄和海拔高度的关系。结果526例ASD患者中合并PAH共360例(68.4%)。二分类logistic回归分析显示,ASD合并PAH的危险因素分别为缺损大小(OR:1.200,95%CI:1.156。1.246,P=0.000)、年龄(OR:1.027,95%CI:1.003—1.052,P=0.025)和海拔高度(OR:1.389,95%CI:1.001~1.637,P=0.043);性别和民族对ASD是否合并PAH无影响(P均〉0.05)。卡方趋势检验显示,ASD合并PAH的发生率随年龄的增长而升高(P=0.000)。海拔≥3500m地区ASD合并PAH的标准化率为74.8%,显著高于海拔2000~2499m地区的66.2%(P=0.003)和海拔2500。3499m地区的66.9%(P=0.005)。结论高原地区单纯ASD患者易形成PAH。ASD合并PAH的危险因素分别为缺损大小、年龄和海拔高度,性别和民族对ASD患者合并PAH无影响。 Objective To analyze risk factors of pulmonary arterial hypertension(PAH) in patients with atrial septal defect (ASD) patients living at above 2000 m high altitude area. Methods We retrospectively analyzed the incidence of PAH in 526 ASD patients out of 1178 congenital heart disease patients who were hospitalized in Qinghai cardiovascular hospital between January 2007 to December 2009 and explored the risk factors including gander, age, altitude, defect size and nationalities for developing PAH in ASD patients using binary logistic regression. Results PAH prevalence was 68.4% (360/526) in ASD patients. The risk factors of developing PAH in these ASD patients were defect size (OR:I. 200,95% CI: 1.156-1.246,P=0.000), age(OR:l.027, 95%CI:1.003- 1.052,P=0.025) and altitude(OR: 1. 389,95% CI: 1. 001 - 1. 637 ,P = 0. 043 ) while gender and nationality were not risk factors for PAH. The incidence of developing PAH increased with aging (P = 0. 000). The standardized ratio of PAH at ≥3500 m was 74. 8% which was significantly higher than that at 2000 -2499 m altitude (66. 2% ,P =0. 005 ) and at 2500 - 3499 m altitude ( 66. 9%, P = 0. 005 ). Conclusions The risk for developing PAH is high in patients living at high altitude area. The risk factors of developing PAH in ASD patients living at high altitude are defect size, age and altitude.
作者 祁生贵 金新会 陈秋红 祁国荣 路霖 杨蕾 QI Sheng-gui , JIN Xin-hui, CHEN Qiu-hong, QI Guo-rong, LU Lin, YANG Lei( Central Laboratory, Qinghai Cardio-Cerebrovascular Disease Special Hospital, Xining 810012, China)
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2012年第10期874-877,共4页 Chinese Journal of Cardiology
基金 青海省2010年科技支撑计划项目(2010.N-127)
关键词 房间隔缺损 高血压 肺性 高海拔 低氧 Heart septal defect, atrial Hypertension,pulmonary Altitude Anoxia
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