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酒精依赖患者的决策功能障碍 预览 被引量:6

The characteristics of decision-making impairment alcohol-dependence patients
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摘要 目的探讨酒精依赖患者的风险决策能力。方法将18例酒精依赖患者和22例与其人口学资料相匹配的健康对照作为研究对象,采用爱荷华博弈测试(IGT)进行风险决策能力测试。结果在博弈任务中,酒精依赖组的总不利选择次数与对照组比较差异无显著性[(46.67±6.72掷46.45±12.28),t=0.07,P〉0.05]。采用2(组)×5(阶段)的方差分析比较两组不同阶段的总有利选择:结果发现不同阶段主效应显著[F(0.529)=3.929,P〈0.05];而被试组别主效应[F(0.001)=0.01,P=0.92]和两者的交互作用[(F(0.333)=1.74,P=0.196)]差异无统计学意义。两组被试5个阶段的净得分两两比较显示:对照组在81~100张(block5)的净得分显著高于酒精依赖组(P〈0.05)。结论酒精依赖患者IGT表现受损,可能与眶额叶皮质、杏仁核受损以及多巴胺功能障碍有关。 Objective To explore the characteristics of decision-making impairment in alcohol-dependence pa- tients. Methods A total of 18 individuals with alcohol-dependence were compared with matched health controls on the Iowa gambling task (IGT). Results In Iowa gambling task, the results showed that alcohol-dependence pa- tients selected more disadvantageous cards than health controls, however without significant difference [ (46. 67 ± 6. 72 vs 46. 45 ± 12.28 respectively), t = 0. 07,P 〉 0. 05 ]. A 2 (group) x 5 (block) ANOVA ( analysis of vari- ance) on the scores of advantageous from the gambling task revealed a significant main effect of block IF(0. 529) ---3. 929,P 〈0. 05]. There was no significant main effect of group IF(0. 001) =0. 01, P =0. 92land no interac- tion of group and time [ (F(0. 333) = 1.74,P =0. 196) ]. Comparisons of alcohol-dependence patients and health controls performance on each block revealed net score differences on block 5 (P 〈 O. 05). Conclusion The present study suggests that the performance impairment on IGT might be in alcohol-dependence patients. The deficit of de- cision-making for alcoholics might be attributed to the dysfunction of the orbito-frontal cortex, amygdala and dopa- mine function.
作者 谢成娟 袁莉莉 汪凯 Xie Chengjuan,Yuan Lili ,Wang Kai ( Dept of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022 )
出处 《安徽医科大学学报》 CAS 北大核心 2012年第12期1460-1462,共3页 Acta Universitis Medicinalis Anhui
关键词 酒精依赖 风险决策 爱荷华博弈测试 alcohol dependence decision making Iowa gambling task
作者简介 谢成娟,女,主治医师,博士研究生 汪凯,男,主任医师,教授,博士生导师,责任作者,E—mail:wangkail964@163.com
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