Objective To observe the effect on clearance of serum digoxin in maintenance henxxtialysis patients（MHD） with different modes of blood purification, hemoperfusion（HP） combined with hemodialysis （HD） and conventional hemodialysis（HD）. Methods 30 MHD patients with Oral digoxin maintenance dose （0. 125 nag qod） were selected to accepted the both two kinds of dialysis treatment, HP ＋ HD treatment once a week, HD treatment twice a week, each treatment last 4 hours. Adopting self-control study,each patient was observed before and after blood purification （HP ＋ HD, HI） treatment each respectively）. 60 cases were divided into HD＋ HP group and HD group, 30 eases in each group. The serum concentration of digoxin and urea nitrogen were recorded before and after the treatment The digoxin clearance rate, urea reduction rate （URR） and single-Fool Kt/V （spKt/V） were compared in the two different treatments, Results The serum concentration of digoxin after the treatment of HP ＋ HD and HD were significantly lower than that before treatment （P〈0. 01）. But the digoxin clearance rate of HD＋ HP group was much higher than in the HD group （P〈0. 01 ）. The serum concentration of digoxin as well as the URR and spKt/V of the two groups be- fore the treatment had no difference （P〉0. 05）. Conclusions Both modes of blood purification, HP ＋ HD and HD, had the effect on eliminating the digoxin in the blood. But the effect of HP ＋ HD was much more better than HD.
Journal Of Clinical Nephrology
The serum concentration of digoxin