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奥硝唑与其他抗菌药物对照治疗妇科阴道感染有效性和安全性Meta分析 预览 被引量:10

Meta-analysis on efficacy and safety of ornidazole in the treatment of gynecological infections
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摘要 目的:运用Meta分析方法对奥硝唑与其他抗茵药物治疗妇科常见阴道感染的临床效果进行评价,为其提供循证医学证据。方法:全面检索奥硝唑与其他抗菌药物治疗妇科阴道感染的临床研究文献,按照Meta分析方法,运用RevMan5.1软件对符合条件的所有结果进行分析。结果:共纳入13篇文献,总样本量1553例,其中,试验组777例,对照组776例。Meta分析结果显示,有效性、临床治愈率、安全性及细菌清除率的合并OR值分别为2.83(P〈0.00001)、2.11(P=0.04)、0.25(P〈0.0001)、1.11(P=0.79),表明奥硝唑的疗效优于对照组,并且不良反应的发生率低于对照组,细菌清除率差异没有统计学意义。结论:在治疗妇科阴道感染中,奥硝唑的疗效和安全性优于其他抗茵药物。 Objective: To evaluate the efficacy and safety of omidazole in the treatment of gynecological infections and provide evidence for the clinical therapy. Methods: Literatures on randomized controlled trials of omidazole in the treatment of gynecological infections were collected.Data were analyzed by Rev Man 5.1 software. Results: A total of 13 randomized controlled trials involving 1553 patients (E/C 777/776) with gynecological infections were included.The efficacy, clinical treatment success, safety and bacterial clearance were evaluated.Results of recta-analysis showed that ornidazole was more effective than the other antibiotics in the treatment of gynecological infections, the values of combined OR for efficacy and clinical cure rate were 2.83 (P 〈 0.000 01) and 2.11 (P = 0.04). However, there was less adverse reactions in ornidazole group than in the control group, the value of combined OR was 0.25 (P 〈 0.000 1). There were no statistically difference in clinical treatment success and bacterial eradication rate between the two groups. Conclusion: The efficacy and safety of omidazole were superior to the other antibiotics in the treatmerit of gynecological infections.
作者 秦玉花 刘银萍 王睿 白楠 梁蓓蓓 梅和坤 QIN Yu-hua, LIU Yin-ping, WANG Rui, BAI Nan, LIANG Bei-bei, MEI He-kun(1. Department of Pharmacy, Henan Provincial People's Hospital, Zhengzhou 450003, China; 2. The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China; 3. The Center of Medicine Clinical Research, PLA General Hospital, Beijing 100853, China)
出处 《中国药物应用与监测》 CAS 2013年第1期7-12,共6页
基金 国家科技部十二五重大专项滚动课题项目(2012ZX09303004)
关键词 奥硝唑 妇科阴道感染 随机对照试验 META分析 Omidazole, Gynecological vaginal infection Randomized controlled trial Mcta-analysis
作者简介 秦玉花,主任药师,硕士生导师,研究方向:临床药理学及抗感染药物药理学。Tel:(0371)65580366,E—mail:qinyuhua399@163.com [通信作者]王睿,女,研究员,博士生导师,研究方向:临床药理学及抗感染药物治疗学。Tel:(010)66939409,E-mail:wangrui301@vip.sina.com
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