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高危HPV TCT联合检测对宫颈疾病的诊断价值 预览 被引量:14

Investigation of the diagnostic accuracy of cervical disease with high-risk HPV, TCT detection
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摘要 目的探讨高危型人乳头状瘤病毒(HR_HPV)检测、液基薄层细胞学检测(TCT)对子宫颈上皮内病变及宫颈癌的诊断价值。方法回顾分析960例宫颈标本用第二代杂交捕获法(HC-2)行HR—HPV检测,在202例阳性病例中109例同时进行TCT及宫颈活检,分析100例HR-HPV检测阴性的TCT及宫颈活检结果,评价两种诊断方法在宫颈疾病中的诊断价值。结果HR-HPV及TCT检测阳性率分别为21.04%和60.55%;两者联合检测敏感度、特异度、阳性预测值及阴性预测值分别为99.62%、61.48%、55.45%和98.99%。结论HR-HPV及TCT联合检测具有高敏感度及阴性预测值的特点,可以提高宫颈疾病筛查诊断的准确性。 Objective To explore the diagnostic value of cervical intraepithelial lesions and cervical cancer with high-risk human papillomavirus (HR-HPV) detection. Methods Retrospective analysis was done on the detection of HR-HPV with the second-generation Hybrid Capture (HC-2) in the 960 cervical specimens, the result of 109 cases at the same time TCT and cervical biopsy in 202 cases of HR-HPV positive cases were analyzed, 100 cases of HR-HPV testing negative results were analyzed. The diagnostic value of two diagnostic methods in the screening of cervical disease was evaluated. Results HR-HPV and TCT test positive rate was 21.04%, 60.55 % % combined detection sensitivity, specificity, positive predictive value and negative predictive value were 99.62%, 61.48%, 55.45%, 98.99%. Conclusion HR- HPV and TCT detection was of high sensitivity and negative predictive values, it can improve the diagnostic accuracy of cervical disease screening.
作者 蓝松 杨丽霞 袁依华 LAN-Song ,YANG Li-Xia, YUAN Yi-Hua (1. Department of Pathology,2. Department of Gynecological, The People's Hospital of Pu'er City, Pffer 666000, Yunnan, China)
出处 《西部医学》 2013年第5期685-686,689共3页 Medical Journal of West China
关键词 TCT HR—HPV检测 宫颈活检 宫颈上皮内病变 筛查 TCT HR -HPV testing Cervical biopsy Cervical intraepithelial lesion Screening
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