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EV71型手足口病患儿血清Th1/Th2细胞因子水平分析 预览 被引量:8

Levels of serum Thl/Th2 cytokines in HFMD patients with EV71 infection
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摘要 目的探讨EV71病毒感染所致手足口病患儿血清Thl/Th2细胞因子水平的变化。方法运用BD流式液相多重蛋白定量技术,检测EV71型手足VI病患儿(病例组)和健康儿童(对照组)血清IL-2、IL-4、IL-6、IL-10、TNF-α及IFN-γ的水平。结果收集病例组和对照组样本各30例;病例组、对照组血清IL-6水平P50分别为7.0、1.9pg/ml,IL一10水平Pj。分别为3.4、2.4pg/ml,两组IL-6、IL-10水平比较差异均有统计学意义(P〈0.05);而血清IL-2、IL-4、TNF-α及IFN-γ水平两组差异均无统计学意义(P〉0.05)。结论IL-6和IL-10可能参与了EV71病毒的致病机理。 Abstract:Objective To investigate the levels changes of serum Thl/Th2 cytokines in Hand-Foot-Mouth Disease (HFMD) patients with EV71 infection. Methods The levels of serum IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ in EVTl-infected HFMD patients and healthy children as control were determined using BD Cytometric Bead Array (CBA) technology. Results A total of 30 patients and 30 healthy children enrolled this study. The PS0 values of serum levels in EV71-infected patients and healthy control were 7.0 pg/ml and 1.9 pg/ml for IL-6 (P〈0. 05), respectively; the Ps0 values of serum levels were 3.4 pg/ ml and 2.4 pg/ml for IL-10 (P〈0.05), respectively; There were meaningful statistically differences between the two groups; whereas no statistical differences were observed between the two groups for serum IL-2, IL-4,TNF-αand IFN-γ levels (P〉0. 05). Conclusion IL-6 and IL-10 might be involved in pathogenesis of EVT1 infection.
作者 朱政 郭喜玲 唐震 陆培善 吴涛 陈银 彭海燕 崔仑标 史智扬 ZHU Zheng ,GUO Xi-ling,TANG Zhen, LU Pei-shan,WU Tao,CHEN Yin,PENG Hai-yan,CUI Lun biao,SHI Zhi-yang Jiangsu Province Center for Disease ControZ and Prevention, Nanjing 210009, China
出处 《江苏预防医学》 CAS 2013年第3期6-8,共3页 Jiangsu Journal of Preventive Medicine
关键词 EV71 手足口病 TH1 TH2细胞因子 EV71 HFMD Th1/Th2 cytokines
作者简介 朱政(1979-),男,江苏南京人,助理研究员。主要从事病原微生物研究工作。
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