目的：探讨大剂量利巴韦林联合干扰素治疗慢性丙型肝炎快速病毒学应答不佳者的疗效。方法：收集2009年1月至2012年12月收治的132例慢性丙型肝炎快速病毒学应答不佳者,随机分为A、B、C3组,在干扰素治疗的基础上分别给以不同剂量利巴韦林,比较治疗后3组患者早期病毒学应答（early virological response,EVR）、治疗结束时病毒学应答（end of therapyvirological response,ETVR）、持续病毒学应答（sustained virological response,SVR）的差异。结果：治疗后,A组EVR应答26例,ETVR应答33例,SVR应答21例;B组EVR应答19例,ETVR应答26例,SVR应答21例;C组EVR应答14例,ETVR应答17例,SVR应答13例;3组患者在EVR、ETVR和SVR应答率等差异具有统计学意义,大剂量利巴韦林组（A组）疗效明显优于其他组（P〈0.05）。结论：对于慢性丙型肝炎快速病毒学应答不佳者,使用大剂量利巴韦林联合干扰素治疗可以提高患者的EVR、ETVR和SVR率。
Objective： To evaluate the efficacy of high-dose ribavirin plus interferon for poor virological response in chronic hepatitis C. Methods： The clinical data of 132 cases with poor virological response in chronic hepatitis C were collected from January 2009 to December 2012. According to the different doses of ribavirin, all patients were randomly divided into three groups（groupA, group B , andgroup C）. response rates of the EVR, ETVR and SVR among the three groups were compared . Results： In group A, there were 26 patients achieved EVR, 33 cases reached to ETVR, 21 patients achieved SVR; In group B, there were 19 patients achieved EVR, 26 cases reached to ETVR, 21 patients achieved SVR; In group C, there were 14 patients achieved EVR, 17 cases reached to ETVR, 13 patients achieved SVR. There were statistical differences in the EVR, ETVR and SVR among the three groups. The effect of group A is better than other groups（P0.05）. Conclusion： High-dose ribavirin combined with interferon is an effective treatment for patients with poor virological response by reducing the rate of EVR, ETVR and SVR.
Clinical Medication JOurnal
Chronic hepatitis C