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老年慢性阻塞性肺疾病急性加重期患者T淋巴细胞亚群的变化及免疫干预观察 被引量:10

Study of T lymphocyte subsets changes in elderly patients with acute exacerbation chronic obstructive pulmonary disease and effect of immune intervention
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摘要 目的探讨老年慢性阻塞性肺疾病急性加重期(AECOPD)患者T淋巴细胞亚群的变化及免疫干预的效果。方法选取66例老年AECOPD患者纳入观察组,40例健康老年者纳入对照组,比较两组T淋巴细胞亚群的水平。随机将66例老年AECOPD患者分为常规治疗组和免疫干预组,免疫干预组在常规治疗基础上加用胸腺肽α1,比较两组患者治疗前后T淋巴细胞亚群的变化。结果老年AECOPD患者血清CD3+、CD4+水平、CD4+/cD8+比值均低于对照组,差异有统计学意义(P〈0.05);治疗后,免疫干预组患者血清CD3+、CD4+及CD4+/CD8+比值明显升高,差异有统计学意义(P〈0.05);常规治疗组患者血清CD3+、CD4+、CD8+及CD4+/CD8+比值均无显著变化(P〉0.05)。结论老年AECOPD患者机体存在细胞免疫功能紊乱,予胸腺肽α1治疗可增强患者的免疫功能。 Objective To investigate the T lymphocyte subsets changes in elderly patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) and effect of immune intervention. Methods 66 cases of elderly patients with AECOPD included in the observation group,40 healthy elderly people were included in the control group, the T lymphocyte subsets levels were compared. 66 cases of elderly patients with AECOPD were divided into conventional treatment group and immune intervention group(which treated by thymosin α1 based on the conventional treatment), after treatment, the T lymphocyte subsets levels were compared. Results The levels of serum CD3+ , CD4+ levels, CD4+/ CD8+ in elderly patients with AECOPD were lower than the control group, the difference was of statistically significant (P 〈0.05); After treatment, the CD3+, CD4+ and CD4+/CD8+ in immune intervention group were significantly increased, the difference was of statistically significant ( P〈0.05) ; and the CD3+, CD4+, CD8+ and CD4+/CD8+ in conventional treatment group did not change significantly ( P 〉 0.05). Conclusions Elderly patients with AECOPD are of immune dysfunction, thymosin α1 therapy can enhance the patient's immune function.
作者 贾长龙 隋金华 鹿志军 成伟丽 白彬彬 J IA Chang-long, SUI Jin-hua, LU Zhi-jun, CHENG Wei-li, BAI Binbin. Department of Respiratory Medicine, Beidaihe 281 Hospital, Qinhuangdao 066100 ,China
机构地区 河北省北戴河
出处 《国际呼吸杂志》 2013年第19期1449-1451,共3页 International Journal of Respiration
关键词 慢性阻塞性肺疾病 老年 T淋巴细胞 胸腺肽 Chronic obstructive pulmonary disease Elderly T lymphocytes Thymosin
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