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胸腺切除术治疗眼肌型重症肌无力29例疗效观察 预览 被引量:2

Effect observation of twenty-nine patients with ocular myasthenia gravis treated by thoraco-scopic thymectomy
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摘要 目的探讨眼肌型重症肌无力(ocular myasthenia gravis,oMG)的手术治疗效果。方法29例oMG患者行胸腔镜下胸腺切除术,进行手术疗效的观察随访。结果病理检查示胸腺正常10例,散在增生17例,胸腺瘤2例,平均随访时间18个月。按Osserman标准判断疗效:症状缓解14例(占48.3%),改善10例(占34.5%),无效或恶化5例(占17.2%),有效率82.8%。发病1年及1年内接受手术的患者有效率88.9%(16/18),发病1年后接受手术的患者有效率72.7%(8/11),随访期间无死亡病例。结论胸腺切除术是治疗重症肌无力的有效方法,应早期手术。 Objective To investigate the curative effect of operation treatment for ocular myasthenia gravis. Methods Twen- ty-nine patients with ocular myasthenia gravis were treated with thoracoscopic thymectomy. Follow-up was conducted to observe the cur-ative effect. The curative effect was judged by Osserman standard. Results Pathological examination showed that there were normal thymus in 10 cases, scattered in the hyperplasia in 17 cases, and thymic tumor in two cases. After operation, the cut-off data of follow-up was 1 June 2013. The mean follow-up time was 18 months. It was found symptom remission in 14 cases(48. 3% ) ,improvement in 10 cases (34. 5 % ), no change in 4 cases (13. 8% ), and deterioration in one case( 3.4% ). The rate of total efficiency is 82. 8%. The oper-ation effective rate for the patients whose medical history werel year or less than 1 years was 88.9% ( 16/18), while the operation effec-tive rate for the patients whose medical history were more than 1 years was 72. 7% (8/11). No patients died during the follow-up. Con-clusion Thymectomy is an effective method for treatment of myasthenia gravis,and the operation should be performed at early stage.
作者 张葆勋 李建业 于涛 蒋俭 于磊 ZHANG Bao-xun, LI Jian-ye, YU Tao, JIANG Jian, YU Lei (Department of Thoracic Surgery ,Beijing Tongren Hospital, Capital Medical University ,Beijing 100730, China)
出处 《实用医院临床杂志》 2013年第6期110-111,共2页 Practical Journal of Clinical Medicine
关键词 眼肌型重症肌无力 胸腺增生 胸腔镜下胸腺切除术 Ocular myasthenia gravis Thymus hyperplasia Thoracoscopic thymectomy
作者简介 【通讯作者】李建业
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