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80例中晚期胃癌患者凝血指标及血瘀症状的临床分析 被引量:8

Coagulation indexes and blood stasis symptom in 80 patients with advanced gastric cancer
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摘要 目的客观评价中晚期胃癌患者凝血指标的改变及与中医证候血瘀证临床症状评分的相关性。方法回顾性分析80例中晚期胃癌患者的凝血指标,主要包括凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、纤维蛋白原含量(FIB)、凝血酶凝结时间(TT)、D-二聚体(DD),与正常健康人的凝血指标标准均值相比较,进行统计学分析;参照血瘀证临床症状评分标准,对患者症状体征进行分级、评分。结果中晚期胃癌患者凝血指标中FIB、DD异常升高所占比例最多,差异有统计学意义(P〈0.05);63.7%的患者中医辨证属于血瘀证,且与凝血指标异常存在相关性,有统计学意义(P〈0.05)。结论多数中晚期胃癌患者存在凝血指标异常及中医血瘀证症状,且两者有相关性。 Object To objectively review the correlation between changes of coagulation indexes and symptom scoring of blood stasis syndrome in patients with advanced gastric cancer. Methods The coagulation indexes, including prothrombin time (PT), activated partial thromboplastin time (APTT), fi- brinogen (FIB), thrombin time (TT) and D-direct ( DD), were retrospectively analyzed in 80 patients, and compared with those in normal people. The symptoms and signs of patients were graded and scored ac- cording to scoring standard of clinical symptoms of blood stasis syndrome. Results The percentage of the patients with abnormally higher FIB and DD increased (P 〈 0.05 ). The patients with blood stasis syndrome accounted for 63.7% after TCM syndrome differentiation, which was correlated to abnormal coagulation in- dexes (P 〈 0. 05). Conclusion Most of patients with advanced gastric cancer have abnormal coagulation indexes and symptoms of blood stasis syndrome, which are correlated to each other.
作者 郭晓青 田劭丹 侯丽 刘庆 陈信义 GUO Xiao-qing, TIAN Shao-dan, HOU Li, LIU Qing, CHEN Xin-yi (Department of Hematology and Oncology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700)
出处 《北京中医药大学学报》 CAS CSCD 北大核心 2013年第11期786-788,共3页 Journal of Beijing University of Traditional Chinese Medicine
基金 北京市2012年度科技计划重大项目(No.D131100002213002)
关键词 中晚期胃癌 凝血指标 血瘀证 advanced gastric cancer coagulation indexes blood stasis syndrome
作者简介 郭晓青,女,在读硕士生 通信作者:田劭丹,女,博士,副主任医师,研究方向:中西医结合防治恶性肿瘤,E—mail:oliviatsd@126.com.
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