Objective： To observe the effects of Dingguier paste combination with other drugs and Dinggnier oral drugs on the juvenile rat model of anorexia. Methods： Juvenile rat model of anorexia was established by etiology simulation method. Then the food intake, body weight, the contents of hydrochloric acid and pepsin in gastric juice were observed, and the variation of CCK-8 and β-endorphin in plasma were also detected. Results： Compared to normal rats, the food intake, body weight and the volume of gastric juice of the model rats were significantly decreased. And the contents of CCK-8 in plasma increased obviously in model rats. The symptoms of model rats were relatively accordance with infantile anorexia. Dingguier oral drugs and its combinations with other drugs have partly effects on model rats,particularly Dingguier combi- nations with other drugs can decreased the volume of CCK-8 in plasma in the young rats model of anorexia and increased the volume of β-endorphin in plasma. Conclusion： Dingguier combinations with other drugs have some effects on the juvenile rats model of anorexia.
Pharmacology and Clinics of Chinese Materia Medica
model of anorexia