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口蹄疫病毒前导蛋白的分子生物学研究进展 预览 被引量:1

CHARACTERISTICS OF LEADER PROTEIN OF FOOT-AND-MOUTH DISEASE VIRUS
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摘要 口蹄疫病毒(Foot-and-mouth disease virus ,FMDV)编码的前导蛋白,不仅是一个重要的蛋白酶,而且对于病毒来说是一个重要的毒力因子,其能够作用于宿主细胞的特异性蛋白,抵抗宿主细胞所产生的抗病毒效应。本文章简述了口蹄疫病毒前导蛋白酶的基本特性,例如前导蛋白的基因结构与病毒复制的关系,前导蛋白酶活性的具体特点,以及前导蛋白影响病毒毒力的分子机制。 Foot-and-mouth disease virus (FMDV) encodes a leader protein, which is not only an important protease but also a crucial virulence factor. The leader protein interacts with specific proteins within host cells, leading to resist cellular defensive mechanisms. The present article summarizes characteristics of the leader protease of FMDV, for example, the relationship of its coding region with viral replication, structure, properties and molecular mechanism affecting viral virulence.
作者 张萌 白兴文 李平花 范朋举 包慧芳 孙普 卢曾军 曹轶梅 刘在新 ZHANG Meng, BAI Xing-wen, LI Ping-hua, FAN Peng-ju, BAO Hui-fang, SUN Pu, LU Zeng-jun, CAO Yi-mei, LIU Zai-xin(State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Engineering Research Center of Biological Detection of Gansu Province, Lanzhou Veterinary Research Institute, CAAS, Lanzhou 730046, China)
出处 《中国动物传染病学报》 CAS 2014年第1期73-79,共7页 Chinese Journal of Veterinary Parasitology
基金 甘肃省科技重大专项计划项目(1102NKDA032)
关键词 口蹄疫病毒 前导蛋白 先天性免疫 Foot-and-mouth disease virus leader protein innate immunity
作者简介 张萌,男,硕士研究生,预防兽医学专业 通信作者:刘在新,E-mail:Liuzaixin@caas.cn
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参考文献31

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