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青年乳腺癌临床病理特点分子分型及预后分析 被引量:58

Clinico pathologic characteristics and molecular phenotypes of young breast cancer patients and their clinical significance
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摘要 目的:探讨青年乳腺癌的临床病理特征、分子分型及预后情况。方法:收集天津医科大学肿瘤医院2002年1月至2009年12月经手术切除、病理证实的133例年龄≤30岁低龄青年乳腺癌病例,及同期117例年龄为31~35岁青年乳腺癌病例,并随机抽取同期年龄>35岁的中老年乳腺癌214例作为对照,回顾性分析其临床病理资料、分子分型及预后情况。结果:低龄青年乳腺癌、31~35岁青年乳腺癌与中老年乳腺癌在肿瘤大小、淋巴结转移、组织学分级、分子分型和肿瘤复发方面差异有统计学意义(P〈0.05)。低龄青年乳腺癌更易出现三阴性乳腺癌、复发及远处转移(P〈0.001),并且低龄青年乳腺癌与31~35岁青年乳腺癌、中老年乳腺癌相比,有较低的总生存率和无病生存率(P〈0.05)。结论:年龄≤35岁青年乳腺癌症状隐匿,预后不佳,与中老年乳腺癌有不同的临床病理特征、分子分型及预后,应重视早期筛查与治疗。 Objective:To study the clinico-pathologic characteristics, molecular phenotypes, and prognosis of young breast can-cer patients. Methods:Data from 133 low-age (age≤30 years) young breast cancer patients and 117 young (31 years≤age≤35 years) breast cancer patients who underwent surgery between January 2002 and December 2009 were reviewed. Cases of the middle and old-age elderly (age>35 years) breast cancer patients during the corresponding period were randomly selected as matched controls. The clinico-pathologic characteristics, molecular phenotypes, and prognosis were retrospectively analyzed. Results:The low-age young and young breast cancer patients significantly differed from the elderly patients in terms of tumor size, lymph node metastasis, histological grading, molecular phenotype, and relapse (P〈0.05). The low-age young patients are more vulnerable to have triple-negative breast can-cer, recurrence, and distant metastasis (P〈0.001). Moreover, the low-age young patients have lower overall survival and disease-free survival than the other groups (P〈0.05). Conclusion:Young breast cancer patients have poor prognosis compared with the elderly. Ear-ly screening and prompt treatment are necessary for young breast cancer patients.
作者 秦颖 张同先 张巍 吕淑华 牛昀 Ying QIN, Tongxian ZHANG, Wei ZHANG, Shuhua LV, Yun NIU (1Department of Breast Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Ministry of Education Key Laboratory of Cancer Prevention and Therapy, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin 300060, China; 2Department of Pathology, Tianjin People's Hospital, Tianjin 300000, China)
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2014年第4期231-236,共6页 Chinese Journal of Clinical Oncology
基金 本文课题受国家自然科学基金项目(编号:81172532)和教育部长江学者和创新团队发展计划项目(编号:TRT0743)资助
关键词 青年乳腺癌 分子分型 预后 临床特点 young breast cancer molecular phenotype prognosis clinico pathologic characteristics
作者简介 秦颖硕士研究生。研究方向为乳腺癌发病机制及早期诊断、乳腺癌转移潜能的预测研究。E-mail:sunshine-kate@163.com. 通信作者:牛昀yunniu2000@126.com
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