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食管癌发生发展过程中环氧合酶—2蛋白表达的研究 预览 被引量:30

A study on cyclooxygenase-2 protein expression in esophageal carcinoma and premalignant lesions
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摘要 目的研究环氧合酶-2 (Cox-2)蛋白在食管癌及癌前病变组织中的表达,探讨非类固醇抗炎药在食管癌高危人群中化学预防的可能性。方法应用免疫组织化学方法检测120例食管癌(原位癌30例,鳞状细胞癌60例,腺癌30例)及其113例增生性病变(单纯增生29例,轻、中、重度不典型增生分别为31例、30例、23例)和27例正常食管黏膜鳞状上皮,以及3例Barrett食管组织中Cox-2蛋白的表达情况。结果在正常食管黏膜上皮,单纯增生,轻、中、重度不典型增生,原位癌未发现有Cox-2蛋白表达;在6%(4/60)侵袭性鳞状细胞癌和70%(21/30)的食管腺癌中,Cox-2蛋白表达阳性。结论 Cox-2蛋白表达可能与食管腺癌的形成有关,而与鳞状细胞癌的发生发展无关。 Objective To investigate cyclooxygenase-2(Cox-2) protein expression in esophageal cancer and precancerous lesions. Methods One hundred twenty biopsy specimens from patients with esophageal carcinoma,113 from patients with esophageal premalingnant lesions,27 from individuals with normal esophageal mucosa and 3 from Barrett's esophagus were examined for Cox-2 protein expression by immunohistochemistry. Results Cox-2 protein was not observed in normal esophageal squamous and glandular epithelium, hyperplasia from mild to severe dysplasia lesions and carcinoma in situ. Positive Cox-2 expression was found in 4 of 60 specimens of invasive squamous-cell carcinomas, 21 of 30 specimens of esophageal adenocarcinomas and in 3 of 3 Barrett′s esophageal tissues. Conclusion The Cox-2 protein expression may be associated with the development of the esophageal adenocarcinomas but not esophageal squamous-cell carcinomas.
作者 王立峰 张伟 王吾如 王洪平 韩双迁 曲平 刘义 李茉 刘伯齐 林培中 WANG Lifeng, ZHANG Wei, WANG Wuru,et al. Department of Pathology, The First Hospital of Harbin Medical University, Harbin 150001,China
出处 《中华肿瘤杂志》 CAS 北大核心 2001年第1期 14-16,共3页 Chinese Journal of Oncology
基金 国家科技攻关项目,国家自然科学基金
关键词 食管肿瘤 癌前病变 环氧合酶-2 食管癌 蛋白表达 Esophageal neoplasms Precancerous conditions Cyclooxygenase-2
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