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江苏省健康儿童脊髓灰质炎免疫水平观察 被引量:13

Observation of Immune Level of Poliomyelitis in Healthy Children in Jiangsu Province for Five Years
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摘要 为了解江苏省健康儿童脊髓灰质炎(脊灰)的免疫状况,进行了0~2月龄婴儿口服脊灰疫苗(OPV)免疫成功率监测,6月龄~、1岁、2岁、3岁、4~9岁儿童脊灰抗体水平监测。1996、1997、1999年儿童OPV免疫成功率监测结果是:Ⅰ型94.6%~98.2%,Ⅱ型98.2%~100.0%,Ⅲ型92.9%~100.0%。1995~1999年健康儿童脊灰抗体水平监测结果是:中和抗体阳性率Ⅰ型为92.3%~100.0%,Ⅱ型94.2%~100.0%,Ⅲ型94.2%~100.0%;中和抗体几何平均滴度Ⅰ、Ⅱ、Ⅲ型分别为1∶55.6~1∶359.2、1∶110.2~1∶188.0、1∶70.8~1∶108.4。说明通过OPV的常规免疫和强化免疫,江苏省儿童对脊灰已形成了牢固的免疫保护。 In order to understand the polio immune level of healthy children in Jiangsu Province, we conducted a survey to find out the immune successful rate of oral polio vaccine (OPV) to 0~2 month old infants and the polio neutralizing antibody level among 6~12 month old to 9 year old children. The results showed that the OPV immune successful rates of infants ranged from 94.6%~98.2%, 98.2% ~100%, 92.9%~100% for Polio Ⅰ, Ⅱ, Ⅲ respectively observed in 1996, 1997 and 1999. The neutralizing antibody positive rates in healthy children in 1995~1999 ranged from 92.3%~100% for polio Ⅰ, 94.2%~100% for Polio Ⅱ, 94.2%~100% for polio Ⅲ and the GMT were 1∶55.6~1∶359.2, 1∶110.2~1∶188.0, 1∶70.8~1∶108.4 for polio Ⅰ, Ⅱ, Ⅲ respectively. These results revealed that a firm protection against poliomyelitis in children in Jiangsu Province has been established through routine and supplementary immunization of OPV.
作者 汤奋扬 冯永庄 冷红英 陆培善 严旭玲 TANG Fen yang, FENG Yong zhuang, LENG Hong ying, et al. Jiangsu Provincial Epidemic Prevention Station, Nanjing 210009, China.
出处 《中国计划免疫》 2001年第1期23-25,共3页 Chinese Journal of Vaccines and Immunization
关键词 脊髓灰质炎 中和抗体 监测 江苏 疫苗 Poliomyelitis Neutralizing antibody Vaccine Surveillance
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