Objective To explore the optimal power of experimental pancreatic endoscopic ultra- sonography （EUS）-guided radiofrequency ablation （RFA） therapy. Methods Six healthy live minipigs were randomly divided into two groups according to random number table, which received RFA under EUS or in ]aparotomy. Each pig in each group was randomly allocated to received RFA at different power （5 W, 10 W, 15 W）. The impedance was monitored and the time for each therapy was recorded. The width diame- ter of coagulation necrosis from RFA was measured by EUS and gross pathology. Results RFA was comple- ted in all pigs smoothly with stable life signs and without complications. Gross and micro pathologic observa- tion confirmed formation of coagulation necrosis lesions. The width diameter of lesions from EUS-RFA was similar to that from surgery RFA, both having a maximum value at 10 W power （11 mm VS 10 ram）. Conclusion The optimal power of experimental pancreatic EUS-RFA in pig is 10W, which should be further explored for the clinical purpose.
Chinese Journal of Digestive Endoscopy