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单胺氧化酶A基因多态性与儿童期虐待对青少年攻击行为的影响 被引量:4

Association of monoamine oxidase A variable number of tandem repeats and child abuse with aggressive behavior among Chinese adolescents
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摘要 目的 探讨单胺氧化酶A串联重复序列(monoamine oxidase A variable number of tandem repeats)基因多态性及儿童期虐待对中国青少年攻击行为影响.方法 采用整群随机抽样法抽取某中学637名年龄13~18岁汉族青少年样本(男388名,女249名),采用儿童创伤经历问卷评定儿童期虐待,采用儿童行为量表评定攻击行为,并从研究对象外周静脉血提取DNA进行MAOA-VNTR基因分型,采用直线回归方法检验儿童期虐待和MAOA-VNTR基因多态性各自对攻击行为的主效应及两者间的交互作用.结果 共有513名(男367名,女146名)进入研究,男性攻击行为平均得分(10.13±6.67)分,女性攻击行为平均得分(9.18 ±6.36)分,不同性别间攻击行为差异无统计学意义(P=0.08).367名男性青少年被试中,MAOA低、高活性组分别为58.3%与41.7%,且不同组间攻击行为得分差异无统计学意义(P=0.93).回归模型显示MAOA基因型对男性青少年攻击行为无预测作用,儿童期虐待经历对攻击行为有显著预测作用(P<0.01),且MAOA基因型与不同类型童年虐待对攻击行为存在显著交互作用(MAOA×虐待总分:P <0.01;MAOA×躯体虐待:P=0.02;MAOA×情感虐待:P <0.01;MAOA×性虐待:P =0.04),MAOA低活性男性在经历儿童期躯体虐待和情感虐待后更易出现攻击倾向;146名女性青少年被试中,MAOA低活性、高活性及杂合子组分别占39.4%、22.5%和38.1%,MAOA不同基因型之间攻击行为得分差异无统计学意义(P=0.69).回归模型显示MAOA基因型对女性青少年攻击行为无预测作用,但儿童期虐待经历对其有显著预测作用(P<0.01),且MAOA与性虐待及MAOA与情感虐待对攻击行为分别存在交互作用(P值分别为0.03和0.04),MAOA低活性女性在受到儿童期性虐待/情感虐待后更易出现攻击倾向.结论 我国13 ~18岁青少年攻击行为受到儿童期虐待经历与MAOA-VNTR基因-环境间交互作 Objective The association of MAOA-VNTR monoamine oxidase A variable number of tandem repeats genotype and child abuse on aggressive behavior among Chinese Han adolescents were examined. Methods A group of 513 ( M :367, F : 146 ) 13-18 years old Chinese adolescents were selected randomly, and the effects of child maltreatment [ measured using the child trauma questionnaire ( CTQ ) 1 and aggressive behavior during adolescents' period [ assessed by the Child Behavior Checklist for Youth Self- Report (YSR) ] were examined respectively. DNA were collected and MAOA-VNTR genotype were assessed via venous blood sample. Both the main effects of MAOA genotype, children's maltreatment experience and the interaction between them were analyzed by a linear regression analysis. Results In all, 513 middle school students (367 boys, 146 girls) were analyzed in the study. The mean aggression scores were (10. 13 ±6. 67) and (9. 18 ± 6.36) for boys and girls. The low and high activity of MAOA-VNTR genotype accounts for 58.3% and 41.7% for boys, and 39. 4% and 22. 5% for girls respectively. The GLM model showed that there were no direct association between the MAOA genotypes with aggression scores, while a significant association between children's maltreatment experience with aggressive behavior in adolescents' period were found for both boys and girls (P 〈 0. 01 ). Some significant interactions between MAOA genotype with subtypes of maltreatment were uncovered ( boys : P = 0. 02, P 〈 0. 01 and P = 0. 04 for MAOA with physical abuse, emotional abuse and sexual abuse; girls: P = 0. 03 and P = 0. 04 for MAOA with sexual and emotional abuse). For adolescents with the low activity of MAOA-VNTR were more prone to commit aggressive behavior when suffered children's abuse for both gender. Conclusions Aggressive behaviors among Chinese adolescents may be affected by a gene-enviornment interaction involving MAOA-VNTR and children's abuse experience which may be differentially sensitiv
作者 张芸 明庆森 朱熊兆 蚁金瑶 姚树桥 Zhang Yun , Ming Qingsen, Zhu Xiongzhao, Yi Jinyao, Yao Shuqiao. * Medical Psychological Institute of the Second Xiangya Hospital, Central South University( Zhang Yun Is Now at Medical Department of North-West University for Nationality, Lanzhou, 730000) , Changsha 410011, China
出处 《中华精神科杂志》 CAS CSCD 北大核心 2014年第2期84-89,共6页 Chinese Journal of Psychiatry
基金 国家科技支撑计划课题(2009BAI77B02) 中央高校基本科研业务费专项资金项目(31920130038)
关键词 单胺氧化酶 多态性 单核苷酸 虐待儿童 攻击 Monoamine oxidase Polymorphism single nucleotide Child abuse Aggression
作者简介 通信作者:姚树桥,Email:shuqiaoyao@163.com
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