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隆安县大规模普种重组酵母乙型肝炎疫苗后的血清学监测结果评价 被引量:7

Serological Survey on the Effect of an Universal Immunization of Newborns with Recombinant Yeast derived Hepatitis B Vaccine in Longan County of Guangxi
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摘要 为了观察国产重组酵母乙型肝炎(乙肝)疫苗的免疫原性和预防效果,在广西壮族自治区隆安县农村地区不筛检孕妇乙肝表面抗原(HBsAg),对新生儿普种国产重组酵母乙肝疫苗,并于免疫后1、2、4年进行血清学监测.结果显示:5μg×3剂国产重组酵母乙肝疫苗初免后,1~4岁儿童的HBsAg阳性率已由免疫前的11.9%降至2.0%,保护率为83.2%;免疫后抗-HBs阳转率峰值为84.4%~88.2%.3~4年下降为71.3%、66.0%,但保护效果不变.可见,国产重组酵母乙肝疫苗具有较好免疫原性,完全可以取代血源性乙肝疫苗纳入计划免疫对新生儿普种. For evaluating the immunogenicity and preventive efficacy of the domestic recombinant yeast-derived hepatitis B vaccine in newborns,we have brought the recombinant yeast-derived hepatitis B vaccine into EPI,and the newborns in the county were universally immunized without screening their mothers’ HBsAgThe serologic surveys were conducted at 1,2 and 4 years after vaccinationThe results showed that after 5μg×3 doses of recombinant yeast-derived hepatitis B vaccination,the HBsAg positive rate decreased from 119% in 1987 before the immunization program to 20% in 2000,the protective rate was 832%The anti-HBs positive seroconversion peak rate observed was 844%-882%,it decreased to 713% and 660% 3 and 4 years later,but the protective rate remained unchangedThis demonstrated that the recombinant yeast-derived hepatitis B vaccine has good immunogenicity and high protection against hepatitis B infection,it may be brought into EPI to replace the plasma-derived hepatitis B vaccine for universal vaccination of newborns
作者 陈修荣 李荣成 农艺 黄兆能 龚健 方孔雄 莫建军 李艳萍 刘崇柏 曹惠霖 赵铠 倪道明 CHEN Xiu-rong,LI Rong-cheng,NONG Yi,et al Epidemic Prevention Station of Longan County,Guangxi Zhuangzu Autonomous Region,Longan 532700,China.
出处 《中国计划免疫》 2001年第3期141-143,共3页 Chinese Journal of Vaccines and Immunization
基金 国家医学科技攻关项目
关键词 重组酵母乙型肝炎疫苗 血清学监测 保护率 疫苗接种 免疫原性 Recombinant yeast-derived hepatitis B vaccine Serological survey Protective efficacy Evaluation
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