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奥美拉唑治疗十二指肠球部溃疡的临床比较研究 预览 被引量:2

Clinical comparison study of Kin-Kong and Losec in the treatment of bulb duodenal ulcer
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摘要 目的:比较国产奥美拉唑(金奥康,验证组,浙江金华康恩贝生物制药有限公司生产)和洛赛克(对照组,阿斯利康制药公司)治疗十二指肠球部溃疡的疗效和安全性.方法:采用随机对照的临床设计.将111例经内窥镜证实十二指肠球部溃疡病患者,分成验证组(91例)和对照组(20例)进行短程治疗.剂量均为每日晨服20 mg,疗程均为4周.结果:验证组和对照组服药前后比较,溃疡愈合率分别为92%和95%(P>0.05),总有效率分别为98%和100%.用药后两者症状均显著改善,且不良反应轻微.结论:国产奥美拉唑(金奥康)是一种安全有效的治疗十二指肠球部溃疡的药物,其疗效和不良反应均与洛赛克相同. OBJECTIVE:To evaluate the effect and safety of Kin Kong in the treatment of duodenal ulcer contrasted with Losec. METHOD:111 patients with the endoscopy proven duodenal ulcer were randomly allocated to treat with Kin Kong and Losec, and both were used in a dose of 20mg P.O daily for 4 weeks.RESULTS:At the end of the treatment, 92% of ulcers were healed with Kin Kong Vs 95% with Losec (P>0.05) , and 98% of ulcers were effective with Kin Kong Vs 100% with Losec. Using Kin Kong and Losec, clinical symptoms of ulcers for both were changed obviously and adverse reactions were slight. CONCLUSION:Kin Kong is a safe and effective drug in the treatment of duodenal ulcer Kin Kong and Losec have the same effect and safety.
作者 张德中 戈之铮 Zhang Dezhong (Zhang DZ), Ge zhizhen(Ge ZZ)(Kin kong clinical study group in shanghaiRenji Affiliated Hospital of Shanghai Second Medical University)
出处 《中国现代应用药学》 CAS CSCD 北大核心 2001年第4期 323-325,共3页 The Chinese Journal of Modern Applied Pharmacy
关键词 金奥康 洛赛克 十二指肠球部溃疡 奥美拉唑 药物疗法 疗效 Kin Kong, Losec, duodenal ulcer, Clinic trial
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